pubmed.ncbi.nlm.nih.gov

Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice - PubMed

Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice

Shalini Pathak et al. Indian J Pharm Sci. 2010 May.

Abstract

In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. The essential oil of the root of Angelica archangelica also produced motor impairment at the antiseizure doses. The study indicated that the essential oil exhibited antiseizure effect. The antiseizure effect may be attributed to the presence of terpenes in the essential oil.

Keywords: Angelica archangelica (Umbelliferae); convulsions; maximal electroshock; medicinal plants; pentylenetetrazol.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1

Effect of AAO on rota rod test Separate groups of mice were injected with vehicle (10 ml/kg, i.p.) or diazepam (4 mg/kg, i.p.) or increasing doses of AAO (50-500 mg/kg, i.p.), and 30 min thereafter motor incordination was tested on rota rod. Each bar represents mean±SEM of data from 5-6 mice. FNx01p<0.05 vs. respective vehicle control and Diazepam control (one-way ANOVA followed by post hoc Dunnett test).

Similar articles

Cited by

References

    1. The Wealth of India, A dictionary of Indian raw materials and industrial products raw materials. A revised ed. Vol 1. New Delhi: Council of Scientifi c and Industrial Research; 2003. pp. 275–6.
    1. Salikhova RA, Poroshenko GG. Antimutagenic properties of Angelica archangelica L. Vestn Ross Akad Med Nauk. 1995;1:58–61. - PubMed
    1. Khayyal MT, el-Ghazaly MA, Kenawy SA, Seif-el-Nasr M, Mahran LG, Kafafi YA, et al. Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination. Arzneimittelforschung. 2001;51:545–53. - PubMed
    1. Yeh ML, Liu CF, Huang CL, Huang TC. Hepatoprotective effect of Angelica archangelica in chronically ethanol-treated mice. Pharmacology. 2003;68:70–3. - PubMed
    1. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S. Antiproliferative effect of Angelica archangelica fruits. Z Naturforsch [C] 2004;59:523–7. - PubMed

LinkOut - more resources