To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms - PubMed

To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms

Aras Toker et al. Sci Signal. 2011.

Abstract

Regulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.

Similar articles

• Epigenetic control of thymic Treg-cell development.

  Kitagawa Y, Ohkura N, Sakaguchi S. Kitagawa Y, et al. Eur J Immunol. 2015 Jan;45(1):11-6. doi: 10.1002/eji.201444577. Epub 2014 Nov 20. Eur J Immunol. 2015. PMID: 25348287 Review.

• Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

  Huehn J, Polansky JK, Hamann A. Huehn J, et al. Nat Rev Immunol. 2009 Feb;9(2):83-9. doi: 10.1038/nri2474. Nat Rev Immunol. 2009. PMID: 19114986 Review.

• Lineage stability and phenotypic plasticity of Foxp3⁺ regulatory T cells.

  Hori S. Hori S. Immunol Rev. 2014 May;259(1):159-72. doi: 10.1111/imr.12175. Immunol Rev. 2014. PMID: 24712465 Review.

• Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

  Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Zheng Y, et al. Nature. 2010 Feb 11;463(7282):808-12. doi: 10.1038/nature08750. Epub 2010 Jan 13. Nature. 2010. PMID: 20072126 Free PMC article.

• Epigenetic and transcriptional control of Foxp3+ regulatory T cells.

  Huehn J, Beyer M. Huehn J, et al. Semin Immunol. 2015 Feb;27(1):10-8. doi: 10.1016/j.smim.2015.02.002. Epub 2015 Mar 20. Semin Immunol. 2015. PMID: 25801206 Review.

Cited by

• Induced and natural regulatory T cells in human cancer.

  Whiteside TL, Schuler P, Schilling B. Whiteside TL, et al. Expert Opin Biol Ther. 2012 Oct;12(10):1383-97. doi: 10.1517/14712598.2012.707184. Epub 2012 Jul 31. Expert Opin Biol Ther. 2012. PMID: 22849383 Free PMC article. Review.

• What are regulatory T cells (Treg) regulating in cancer and why?

  Whiteside TL. Whiteside TL. Semin Cancer Biol. 2012 Aug;22(4):327-34. doi: 10.1016/j.semcancer.2012.03.004. Epub 2012 Mar 28. Semin Cancer Biol. 2012. PMID: 22465232 Free PMC article. Review.

• Epigenetic Variability of CD4+CD25+ Tregs Contributes to the Pathogenesis of Autoimmune Diseases.

  Shu Y, Hu Q, Long H, Chang C, Lu Q, Xiao R. Shu Y, et al. Clin Rev Allergy Immunol. 2017 Apr;52(2):260-272. doi: 10.1007/s12016-016-8590-3. Clin Rev Allergy Immunol. 2017. PMID: 27687891 Review.

• The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review.

  Bannister S, Messina NL, Novakovic B, Curtis N. Bannister S, et al. Epigenetics. 2020 Jun-Jul;15(6-7):555-593. doi: 10.1080/15592294.2020.1712814. Epub 2020 Mar 17. Epigenetics. 2020. PMID: 31914857 Free PMC article.

• Self-tolerance in multiple sclerosis.

  Gonsette RE. Gonsette RE. Acta Neurol Belg. 2012 Jun;112(2):133-40. doi: 10.1007/s13760-012-0061-x. Epub 2012 Mar 24. Acta Neurol Belg. 2012. PMID: 22450711 Free PMC article. Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Research Materials

  • NCI CPTC Antibody Characterization Program