Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies - PubMed

Affiliations

• PMID: 21354783
• DOI: 10.1016/j.ejca.2011.01.020

Review

Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies

Alice Wallin et al. Eur J Cancer. 2011 Jul.

Abstract

Excess body weight has been identified as a risk factor for various cancer types. Since the publication of two meta-analyses indicating that body mass index (BMI) is positively associated with the risk of multiple myeloma, the evidence from prospective cohort studies on this issue has largely accumulated. We therefore conducted a meta-analysis to update and expand the previous results. We searched the PubMed and EMBASE databases through 26 January 2011 and reviewed the reference lists of retrieved articles. Prospective cohort studies were included if they reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between BMI and multiple myeloma incidence or mortality. A random-effects model was used to combine study-specific results. A total of 15 cohort studies on multiple myeloma incidence and five studies on multiple myeloma mortality were included in the meta-analysis. Compared with subjects in the normal weight category, the risk of multiple myeloma was statistically significantly elevated among subjects categorised as overweight (RR, 1.12; 95% CI, 1.07-1.18) or obese (RR, 1.21; 95% CI, 1.08-1.35). For multiple myeloma mortality, the corresponding summary RR estimates were 1.15 (95% CI, 1.04-1.27) and 1.54 (95% CI, 1.35-1.76). Results from this meta-analysis are in line with the conclusions of the previous meta-analyses, and suggest that excess body weight is a risk factor for multiple myeloma.

Similar articles

• Body mass index and risk of multiple myeloma: a meta-analysis.

  Larsson SC, Wolk A. Larsson SC, et al. Int J Cancer. 2007 Dec 1;121(11):2512-6. doi: 10.1002/ijc.22968. Int J Cancer. 2007. PMID: 17680557

• Body mass index and risk of non-Hodgkin's and Hodgkin's lymphoma: a meta-analysis of prospective studies.

  Larsson SC, Wolk A. Larsson SC, et al. Eur J Cancer. 2011 Nov;47(16):2422-30. doi: 10.1016/j.ejca.2011.06.029. Epub 2011 Jul 4. Eur J Cancer. 2011. PMID: 21733676 Review.

• The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies.

  Abdullah A, Peeters A, de Courten M, Stoelwinder J. Abdullah A, et al. Diabetes Res Clin Pract. 2010 Sep;89(3):309-19. doi: 10.1016/j.diabres.2010.04.012. Epub 2010 May 20. Diabetes Res Clin Pract. 2010. PMID: 20493574

• Body mass index, abnormal glucose metabolism, and mortality from hematopoietic cancer.

  Chiu BC, Gapstur SM, Greenland P, Wang R, Dyer A. Chiu BC, et al. Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2348-54. doi: 10.1158/1055-9965.EPI-06-0007. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 17164355

• Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies.

  Chen Y, Wang X, Wang J, Yan Z, Luo J. Chen Y, et al. Eur J Cancer. 2012 Sep;48(14):2137-45. doi: 10.1016/j.ejca.2012.02.063. Epub 2012 Mar 23. Eur J Cancer. 2012. PMID: 22446023 Review.

Cited by

• Body size in relation to incidence of subtypes of haematological malignancy in the prospective Million Women Study.

  Murphy F, Kroll ME, Pirie K, Reeves G, Green J, Beral V. Murphy F, et al. Br J Cancer. 2013 Jun 11;108(11):2390-8. doi: 10.1038/bjc.2013.159. Epub 2013 May 2. Br J Cancer. 2013. PMID: 23640394 Free PMC article.

• Disparities in Outcomes of Hospitalizations Due to Multiple Myeloma: A Nationwide Comparison.

  Khadka S, Balaji S, Kaur J, Solanki D, Kasianchyk M, Chowdhury H, Patel I, Qasim M, Desai M, Maiyani P, Moradiya DV, Lal D, Patel AA, Lekkala M. Khadka S, et al. Cureus. 2023 Oct 19;15(10):e47319. doi: 10.7759/cureus.47319. eCollection 2023 Oct. Cureus. 2023. PMID: 38022254 Free PMC article.

• Abnormal Plasma Cell Disorders in Refinery Waste Workers.

  Ledda C, Loreto C, Filetti V, Matera S, Vitale E, Bracci M, Rapisarda V. Ledda C, et al. J Clin Med. 2018 Aug 17;7(8):221. doi: 10.3390/jcm7080221. J Clin Med. 2018. PMID: 30126157 Free PMC article.

• Dietary intake is associated with risk of multiple myeloma and its precursor disease.

  Thordardottir M, Lindqvist EK, Lund SH, Costello R, Burton D, Steingrimsdottir L, Korde N, Mailankody S, Eiriksdottir G, Launer LJ, Gudnason V, Harris TB, Landgren O, Torfadottir JE, Kristinsson SY. Thordardottir M, et al. PLoS One. 2018 Nov 1;13(11):e0206047. doi: 10.1371/journal.pone.0206047. eCollection 2018. PLoS One. 2018. PMID: 30383820 Free PMC article.

• Body mass index associated with monoclonal gammopathy of undetermined significance (MGUS) progression in Olmsted County, Minnesota.

  Kleinstern G, Larson DR, Allmer C, Norman AD, Muntifering G, Sinnwell J, Visram A, Rajkumar V, Dispenzieri A, Kyle RA, Slager SL, Kumar S, Vachon CM. Kleinstern G, et al. Blood Cancer J. 2022 Apr 19;12(4):67. doi: 10.1038/s41408-022-00659-9. Blood Cancer J. 2022. PMID: 35440099 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Medical

  • MedlinePlus Health Information