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The placebo effect and the autonomic nervous system: evidence for an intimate relationship - PubMed

️Sat Jan 01 2011

Review

The placebo effect and the autonomic nervous system: evidence for an intimate relationship

Karin Meissner. Philos Trans R Soc Lond B Biol Sci. 2011.

Abstract

For many subjectively experienced outcomes, such as pain and depression, rather large placebo effects have been reported. However, there is increasing evidence that placebo interventions also affect end-organ functions regulated by the autonomic nervous system (ANS). After discussing three psychological models for autonomic placebo effects, this article provides an anatomical framework of the autonomic system and then critically reviews the relevant placebo studies in the field, thereby focusing on gastrointestinal, cardiovascular and pulmonary functions. The findings indicate that several autonomic organ functions can indeed be altered by verbal suggestions delivered during placebo and nocebo interventions. In addition, three experimental studies provide evidence for organ-specific effects, in agreement with the current knowledge on the central control of the ANS. It is suggested that the placebo effects on autonomic organ functions are best explained by the model of 'implicit affordance', which assumes that placebo effects are dependent on 'lived experience' rather than on the conscious representation of expected outcomes. Nevertheless, more studies will be needed to further elucidate psychological and neurobiological pathways involved in autonomic placebo effects.

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References

1. Hróbjartsson A., Gøtzsche P. C. 2001. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N. Engl. J. Med. 344, 1594–160210.1056/NEJM200105243442106 (doi:10.1056/NEJM200105243442106) - DOI - DOI - PubMed
1. Hróbjartsson A., Gøtzsche P. C. 2004. Placebo interventions for all clinical conditions. Cochrane Database Syst. Rev. CD003974.10.1002/14651858.CD003974.pub2 (doi:10.1002/14651858.CD003974.pub2) - DOI - DOI - PubMed
1. Hróbjartsson A., Gøtzsche P. C. 2004. Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment. J. Intern. Med. 256, 91–10010.1111/j.1365-2796.2004.01355.x (doi:10.1111/j.1365-2796.2004.01355.x) - DOI - DOI - PubMed
1. Hróbjartsson A., Gøtzsche P. C. 2010. Placebo interventions for all clinical conditions. Cochrane Database Syst. Rev. CD003974.10.1002/14651858.CD003974.pub3 (doi:10.1002/14651858.CD003974.pub3) - DOI - DOI - PMC - PubMed
1. Meissner K., Distel H., Mitzdorf U. 2007. Evidence for placebo effects on physical but not on biochemical outcome parameters: a review of clinical trials. BMC Med. 5, 3.10.1186/1741-7015-5-3 (doi:10.1186/1741-7015-5-3) - DOI - DOI - PMC - PubMed

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The placebo effect and the autonomic nervous system: evidence for an intimate relationship - PubMed