Is early nutrition related to short-term health and long-term outcome? - PubMed

Affiliations

• PMID: 21701166
• DOI: 10.1159/000323465

Is early nutrition related to short-term health and long-term outcome?

Hania Szajewska et al. Ann Nutr Metab. 2011.

Abstract

This paper summarizes the literature concerning the effects of administering (1) long-chain polyunsaturated fatty acids (LCPUFA), (2) probiotics and/or (3) prebiotics to preterm infants. Clinically relevant, short- and long-term efficacy outcomes, such as those related to a reduced risk of disease, as well as outcomes related to safety, were sought. MEDLINE and the Cochrane Library literature searches performed in September 2010 were limited to randomized controlled trials, their systematic reviews or meta-analyses. LCPUFA supplementation, particularly docosahexaenoic acid (DHA), of infant formula for preterm infants has consistently demonstrated better visual development of preterm infants compared with unsupplemented formulas. There is increasing evidence to suggest that LCPUFA supplementation for preterm infants is also related to improvements in more global measures of development, without any adverse effects. It is, however, important to note that the DHA doses tested in the infant formula interventions for preterm infants have been rather conservative. Newer studies comparing dietary DHA concentrations that match in utero accumulation rates with dietary DHA concentrations typical in the milk of women consuming little fish or in supplemented infant formulas demonstrate that these higher DHA doses are related to improvements in domains of cognitive development. Although further work is needed to better understand the optimal DHA requirements of preterm infants, it is clear that a dietary source of DHA is important to support neurodevelopment. To date, the most promising application of probiotics in preterm infants is the prevention of necrotizing enterocolitis by the administration of certain probiotics. Many other benefits of administering probiotics and/or prebiotics to preterm infants are, however, largely unproven. Efficacy and safety should be established for each probiotic and/or prebiotic product. Further research should specify strain-specific outcomes and determine optimal dosing schedules. Safety and long-term follow-up studies are of particular interest.

Similar articles

• Lipid needs of preterm infants: updated recommendations.

  Lapillonne A, Groh-Wargo S, Gonzalez CH, Uauy R. Lapillonne A, et al. J Pediatr. 2013 Mar;162(3 Suppl):S37-47. doi: 10.1016/j.jpeds.2012.11.052. J Pediatr. 2013. PMID: 23445847

• Reevaluation of the DHA requirement for the premature infant.

  Lapillonne A, Jensen CL. Lapillonne A, et al. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):143-50. doi: 10.1016/j.plefa.2009.05.014. Epub 2009 Jul 5. Prostaglandins Leukot Essent Fatty Acids. 2009. PMID: 19577914 Review.

• Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants.

  Fewtrell MS, Abbott RA, Kennedy K, Singhal A, Morley R, Caine E, Jamieson C, Cockburn F, Lucas A. Fewtrell MS, et al. J Pediatr. 2004 Apr;144(4):471-9. doi: 10.1016/j.jpeds.2004.01.034. J Pediatr. 2004. PMID: 15069395 Clinical Trial.

• Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth.

  Makrides M, Smithers LG, Gibson RA. Makrides M, et al. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:123-33; discussion 133-6. doi: 10.1159/000281154. Epub 2010 Feb 1. Nestle Nutr Workshop Ser Pediatr Program. 2010. PMID: 20139678 Review.

• Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids.

  Hoffman DR, Wheaton DK, James KJ, Tuazon M, Diersen-Schade DA, Harris CL, Stolz S, Berseth CL. Hoffman DR, et al. J Pediatr Gastroenterol Nutr. 2006 Mar;42(3):287-92. doi: 10.1097/01.mpg.0000189366.91792.64. J Pediatr Gastroenterol Nutr. 2006. PMID: 16540798 Clinical Trial.

Cited by

• DHA supplementation: current implications in pregnancy and childhood.

  Rogers LK, Valentine CJ, Keim SA. Rogers LK, et al. Pharmacol Res. 2013 Apr;70(1):13-9. doi: 10.1016/j.phrs.2012.12.003. Epub 2012 Dec 21. Pharmacol Res. 2013. PMID: 23266567 Free PMC article. Review.

• [Homologous human milk supplement for very low birth weight preterm infant feeding].

  Grance TR, Serafin Pde O, Thomaz DM, Palhares DB. Grance TR, et al. Rev Paul Pediatr. 2015 Jan-Mar;33(1):28-33. doi: 10.1016/j.rpped.2014.07.001. Epub 2015 Feb 3. Rev Paul Pediatr. 2015. PMID: 25662564 Free PMC article.

• Optimizing Nutrition in Preterm Low Birth Weight Infants-Consensus Summary.

  Kumar RK, Singhal A, Vaidya U, Banerjee S, Anwar F, Rao S. Kumar RK, et al. Front Nutr. 2017 May 26;4:20. doi: 10.3389/fnut.2017.00020. eCollection 2017. Front Nutr. 2017. PMID: 28603716 Free PMC article. Review.

• Effect of Fortification of Breast Milk in Conjugation with Protein Supplement on Neurodevelopment of Preterm Low Birth Weight Infants at 3 Years.

  Kashaki M, Samghabadi FM, Bordbar A. Kashaki M, et al. Med Arch. 2019 Oct;73(5):344-350. doi: 10.5455/medarh.2019.73.344-350. Med Arch. 2019. PMID: 31819309 Free PMC article. Clinical Trial.

• n-3 LC-PUFA supplementation: effects on infant and maternal outcomes.

  De Giuseppe R, Roggi C, Cena H. De Giuseppe R, et al. Eur J Nutr. 2014 Aug;53(5):1147-54. doi: 10.1007/s00394-014-0660-9. Epub 2014 Jan 22. Eur J Nutr. 2014. PMID: 24448975 Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • S. Karger AG, Basel, Switzerland

• Medical

  • MedlinePlus Health Information