Replication of HIV-1 in a wide variety of animal cells following phenotypic mixing with murine retroviruses - PubMed

Comparative Study

Replication of HIV-1 in a wide variety of animal cells following phenotypic mixing with murine retroviruses

M Canivet et al. Virology. 1990 Oct.

Abstract

Human T cells co-infected with the human immunodeficiency virus type 1 (HIV-1) and the xenotropic or dual-tropic mouse type C virus (MuLV) give rise, by phenotypic mixing, to progeny virus that can transfer HIV-1 into a wide variety of mammalian and avian cells. Differences in the extent of HIV-1 replication in these animal cells can be observed. Replication is best in human cells, but occurs substantially in cells from many animal species including mink, horse, and bush wallaby. Virus production in murine and avian cells is very limited. These results confirm that the major block to HIV-1 infection of animal cells is at the cellular surface but that intracellular regulation of viral replication is also involved. Moreover, an enhancement of HIV-1 cytopathic effects can be seen in human cells co-infected by MuLV. All these data suggest phenotypically mixed viruses might be useful for developing an animal model system for studying AIDS, and that the pathological expression of HIV-1 could be modified by the presence in cells of other retroviruses. They also indicate a potential mechanism by which HIV strains can be generated with an increased ability to spread in nature.

Similar articles

• Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses.

  Lusso P, di Marzo Veronese F, Ensoli B, Franchini G, Jemma C, DeRocco SE, Kalyanaraman VS, Gallo RC. Lusso P, et al. Science. 1990 Feb 16;247(4944):848-52. doi: 10.1126/science.2305256. Science. 1990. PMID: 2305256

• Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo.

  Hinkula J, Rollman E, Lundholm P, Benthin R, Okuda K, Wahren B. Hinkula J, et al. Cells Tissues Organs. 2004;177(3):169-84. doi: 10.1159/000079991. Cells Tissues Organs. 2004. PMID: 15388991

• Serodiagnosis of infection with the AIDS virus and other human retroviruses.

  Schochetman G, Epstein JS, Zuck TF. Schochetman G, et al. Annu Rev Microbiol. 1989;43:629-59. doi: 10.1146/annurev.mi.43.100189.003213. Annu Rev Microbiol. 1989. PMID: 2679365 Review. No abstract available.

Cited by

• Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses.

  Koval V, Clark C, Vaishnav M, Spector SA, Spector DH. Koval V, et al. J Virol. 1991 Dec;65(12):6969-78. doi: 10.1128/JVI.65.12.6969-6978.1991. J Virol. 1991. PMID: 1658386 Free PMC article.

• Altering the tropism of lentiviral vectors through pseudotyping.

  Cronin J, Zhang XY, Reiser J. Cronin J, et al. Curr Gene Ther. 2005 Aug;5(4):387-98. doi: 10.2174/1566523054546224. Curr Gene Ther. 2005. PMID: 16101513 Free PMC article. Review.

• Enhanced central nervous system transduction with lentiviral vectors pseudotyped with RVG/HIV-1gp41 chimeric envelope glycoproteins.

  Trabalza A, Eleftheriadou I, Sgourou A, Liao TY, Patsali P, Lee H, Mazarakis ND. Trabalza A, et al. J Virol. 2014 Mar;88(5):2877-90. doi: 10.1128/JVI.03376-13. Epub 2013 Dec 26. J Virol. 2014. PMID: 24371049 Free PMC article.

• Clinical applications involving CNS gene transfer.

  Kantor B, McCown T, Leone P, Gray SJ. Kantor B, et al. Adv Genet. 2014;87:71-124. doi: 10.1016/B978-0-12-800149-3.00002-0. Adv Genet. 2014. PMID: 25311921 Free PMC article. Review.

• Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles.

  Reiser J, Harmison G, Kluepfel-Stahl S, Brady RO, Karlsson S, Schubert M. Reiser J, et al. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15266-71. doi: 10.1073/pnas.93.26.15266. Proc Natl Acad Sci U S A. 1996. PMID: 8986799 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations Database