High density lipoprotein is a scavenger of superoxide anions - PubMed

Affiliations

• PMID: 2171536
• DOI: 10.1016/0006-2952(90)90469-2

Comparative Study

High density lipoprotein is a scavenger of superoxide anions

R Chander et al. Biochem Pharmacol. 1990.

Abstract

Present work describes a new property of HDL to act as a scavenger of O2- free radicals in vitro. This lipoprotein prevents both enzymic and non-enzymic generation of O2- anions as evidenced by inhibition of xanthine oxidase, peroxidase, peroxidation of pyrogallol and phenazine methosulphate-NADH reaction. Ascorbate stimulated MDA formation in microsomes has been shown to be suppressed by HDL and these effects are comparable with that of BHA.

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