Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats - PubMed

Schematic of the pontomedullary respiratory/cough network model showing simulated populations and network connections. Large colored circles represent simulated populations. To facilitate the tracing of pathways, regional connections are color coded and dots mark branch points of divergent projections. This model includes specific enhancements of a prior model (119) as described in

results

, including an evidence-based raphé circuit with baroreceptor-related neuorns interconnected with the pontomedullary respiratory network and more speculative functional connections (see key). Added neuronal populations and model parameters for cell properties and connections are detailed in Supplemental Tables S1-S4. Aug, units with augmenting activity; BötC, Bötzinger complex; BS, bulbo-spinal; c, caudal; Dec, units with decrementing activity; E, expiratory neurons; E-Dec-pre, E-Dec premotor units excitatory to ELM; EI, neurons with a peak firing rate during the expiratory-inspiratory phase transition and with a Dec activity in inspiratory phase; ELM, expiratory laryngeal motoneurons; I, inspiratory neurons; I driver, excitatory inspiratory neurons with activity onset in the late expiratory phase with conditional bursting pacemaker properties; IE, neurons with a peak firing rate during the inspiratory-expiratory phase transition and with a Dec activity in expiratory phase; ILM, inspiratory laryngeal motoneurons; Lum, lumbar; NRM, nonrespiratory modulated neurons; NTS, solitary tract nucleus; P, phasic; Phr, phrenic; pre-BötC, pre-Bötzinger complex; PRG, pontine respiratory group; PSR, pulmonary stretch receptors; r, rostral; T, tonic; VRC or VRG, ventral respiratory column or group.