pubmed.ncbi.nlm.nih.gov

The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients - PubMed

The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients

Andrzej Jakubczyk et al. J Psychiatr Res. 2012 Jan.

Abstract

High levels of impulsivity can increase the vulnerability for development of alcohol dependence. Moreover, impulsivity is considered to be a predictor of poor treatment outcomes. Few studies, however, have directly examined the genetics of impulsivity in alcohol-dependent patients. We analyzed the relationships between a well-recognized genetic marker of serotonin activity and levels of impulsivity as measured by both the Barratt Impulsiveness Scale (BIS-11) and the stop-signal task among 304 alcohol-dependent patients. The stop-signal task was used as an independent, objective method of estimating the level of behavioral impulsivity, and the BIS-11 as a self-report measure of global impulsivity. Blood was collected and analyzed for the T102C (rs6313) polymorphism in the serotonin type 2A receptor gene (HTR2A). Our results indicate a significant association between high levels of behavioral impulsivity and the C/C genotype of rs6313 in alcohol-dependent patients. The CC genotype has been previously found to be associated with a reduction in 5HT2A receptors in the central nervous system. These results support the hypothesis that genetic factors are important determinants of behavioral impulsivity in alcohol-dependent patients, and that the serotonin system plays an important role in establishing its level.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

All authors declare that they have no conflicts of interest.

Figures

**Figure 1**
Association of T allele in *HTR2A (rs6313)* gene polymorphism and level of behavioral impulsivity in alcohol-dependent patients.

Cited by

BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia.
Morozova A, Ushakova V, Pavlova O, Bairamova S, Andryshenko N, Ochneva A, Abramova O, Zorkina Y, Spektor VA, Gadisov T, Ukhov A, Zubkov E, Solovieva K, Alexeeva P, Khobta E, Nebogina K, Kozlov A, Klimenko T, Gurina O, Shport S, Kostuyk G, Chekhonin V, Pavlov K. Morozova A, et al. Genes (Basel). 2024 Feb 14;15(2):240. doi: 10.3390/genes15020240. Genes (Basel). 2024. PMID: 38397229 Free PMC article.
Impulsivity, risky behaviors and accidents in alcohol-dependent patients.
Jakubczyk A, Klimkiewicz A, Wnorowska A, Mika K, Bugaj M, Podgórska A, Barry K, Blow FC, Brower KJ, Wojnar M. Jakubczyk A, et al. Accid Anal Prev. 2013 Mar;51:150-5. doi: 10.1016/j.aap.2012.11.013. Epub 2012 Dec 12. Accid Anal Prev. 2013. PMID: 23246707 Free PMC article.
Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes.
Ashare RL, Norris CJ, Wileyto EP, Cacioppo JT, Strasser AA. Ashare RL, et al. Pers Individ Dif. 2013 Sep 1;55(5):469-473. doi: 10.1016/j.paid.2013.04.009. Pers Individ Dif. 2013. PMID: 23976810 Free PMC article.
Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.
McKay L, Petrelli B, Pind M, Reynolds JN, Wintle RF, Chudley AE, Drögemöller B, Fainsod A, Scherer SW, Hanlon-Dearman A, Hicks GG. McKay L, et al. Biomolecules. 2024 May 10;14(5):569. doi: 10.3390/biom14050569. Biomolecules. 2024. PMID: 38785976 Free PMC article.

References

1. Arce E, Santisteban C. Impulsivity: a review. Psicothema. 2006;18:213–220. - PubMed
1. Audenaert K, Goethals I, Van Laere K, Lahorte P, Brans B, Versijpt J, et al. SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients. Nuclear Medicine Communications. 2002;23:907–916. - PubMed
1. Band GP, van der Molen MW, Logan GD. Horse-race model simulations of the stop-signal procedure. Acta Psychologica. 2003;112:105–142. - PubMed
1. Bjork JM, Moeller FG, Dougherty DM, Swann AC, Machado MA, Hanis CL. Serotonin 2a receptor T102C polymorphism and impaired impulse control. American Journal of Medical Genetics. 2002;114:336–339. - PubMed
1. Bondy B, Kuznik J, Baghai T, Schule C, Zwanzger P, Minov C, et al. Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. American Journal of Medical Genetics. 2000;96:831–835. - PubMed

The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients - PubMed