pubmed.ncbi.nlm.nih.gov

The lymphatic vasculature in disease - PubMed

  • ️Sat Jan 01 2011

Review

. 2011 Nov 7;17(11):1371-80.

doi: 10.1038/nm.2545.

Affiliations

Review

The lymphatic vasculature in disease

Kari Alitalo. Nat Med. 2011.

Abstract

Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic vessels is to collect excess protein-rich fluid that has extravasated from blood vessels and transport it back into the blood circulation. Lymphatic vessels have an important immune surveillance function, as they import various antigens and activated antigen-presenting cells into the lymph nodes and export immune effector cells and humoral response factors into the blood circulation. Defects in lymphatic function can lead to lymph accumulation in tissues, dampened immune responses, connective tissue and fat accumulation, and tissue swelling known as lymphedema. This review highlights the most recent developments in lymphatic biology and how the lymphatic system contributes to the pathogenesis of various diseases involving immune and inflammatory responses and its role in disseminating tumor cells.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Exp Med. 2009 Dec 21;206(13):2925-35 - PubMed
    1. Nature. 2010 Oct 28;467(7319):1109-13 - PubMed
    1. Transplantation. 2011 Jul 15;92(1):25-30 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1906-11 - PubMed
    1. Cell. 1999 Sep 17;98(6):769-78 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources