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ARID2: a new tumor suppressor gene in hepatocellular carcinoma - PubMed

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ARID2: a new tumor suppressor gene in hepatocellular carcinoma

Hong Zhao et al. Oncotarget. 2011 Nov.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.

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Figures

Figure 1
Figure 1. Somatic ARID2alterations identified in HCC

a, Somatic alterations identified in the ARID2 gene. *, nonsense mutations; #, frame-shifting indels; &, splice site mutation. b, ARID2 protein and the inactivating alterations (red arrows) Truncating mutations are indicated by red arrows. ARID, AT-rich interaction domain; RFX, RFX-like DNA binding motif; GLN, Proline-and glutamine-rich region; ZnF, C2H2 Zinc Fingers.

Figure 2
Figure 2. Schematic representation of the PBAF complex containing ARID2 (BAF200) which is involved in the transcriptional initiation of the human IFN-α/β/γ genes

IFN, Interferon; IFNAR, Interferon-α/β/γ receptor; PBAF, Polybromo-associated BRG1-associated factor; ISRE, Interferon-sensitive response element; GAS, Interferon-γ-activated site; STAT1, Signal transducers and activators of transcription 1.

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