Meta-analysis of statin effects in women versus men - PubMed
- ️Sun Jan 01 2012
Review
. 2012 Feb 7;59(6):572-82.
doi: 10.1016/j.jacc.2011.09.067.
Affiliations
- PMID: 22300691
- DOI: 10.1016/j.jacc.2011.09.067
Free article
Review
Meta-analysis of statin effects in women versus men
William J Kostis et al. J Am Coll Cardiol. 2012.
Free article
Erratum in
- J Am Coll Cardiol. 2012 Apr 17;59(16):1491
Abstract
Objectives: The aim of this study was to evaluate the effect of statins in decreasing cardiovascular events in women and men.
Background: Published data reviews have suggested that statins might not be as effective in women as in men in decreasing cardiovascular events.
Methods: Published data searches and contacts with investigators identified 18 randomized clinical trials of statins with sex-specific outcomes (N = 141,235, 40,275 women, 21,468 cardiovascular events). Odds ratios (ORs) and 95% confidence intervals (CIs) for cardiovascular events were calculated for women and men separately with random effects meta-analyses.
Results: The cardiovascular event rate was lower among those randomized to statin intervention than in those randomized to control (low-dose statin in 4 studies, placebo in 11 studies, usual care in 3 studies) and similar in women and men (OR: 0.81, 95% CI: 0.75 to 0.89; p < 0.0001, and OR: 0.77, 95% CI: 0.71 to 0.83, p < 0.0001, respectively). The benefit of statins was statistically significant in both sexes, regardless of the type of control, baseline risk, or type of endpoint and in both primary and secondary prevention. All-cause mortality was also lower with statin therapy both in women and men without significant interaction by sex (p for interaction = 0.4457).
Conclusions: Statin therapy is associated with significant decreases in cardiovascular events and in all-cause mortality in women and men. Statin therapy should be used in appropriate patients without regard to sex.
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Comment in
-
Controversy and consensus about statin use: it is not about the sex.
Mosca L. Mosca L. J Am Coll Cardiol. 2012 Feb 7;59(6):583-4. doi: 10.1016/j.jacc.2011.11.008. J Am Coll Cardiol. 2012. PMID: 22300692 No abstract available.
Similar articles
-
Statin therapy in the prevention of recurrent cardiovascular events: a sex-based meta-analysis.
Gutierrez J, Ramirez G, Rundek T, Sacco RL. Gutierrez J, et al. Arch Intern Med. 2012 Jun 25;172(12):909-19. doi: 10.1001/archinternmed.2012.2145. Arch Intern Med. 2012. PMID: 22732744 Review.
-
Impact of gender on statin efficacy.
Dale KM, Coleman CI, Shah SA, Patel AA, Kluger J, White CM. Dale KM, et al. Curr Med Res Opin. 2007 Mar;23(3):565-74. doi: 10.1185/030079906X167516. Curr Med Res Opin. 2007. PMID: 17355737 Review.
-
Mills EJ, Rachlis B, Wu P, Devereaux PJ, Arora P, Perri D. Mills EJ, et al. J Am Coll Cardiol. 2008 Nov 25;52(22):1769-81. doi: 10.1016/j.jacc.2008.08.039. J Am Coll Cardiol. 2008. PMID: 19022156
-
Petretta M, Costanzo P, Perrone-Filardi P, Chiariello M. Petretta M, et al. Int J Cardiol. 2010 Jan 7;138(1):25-31. doi: 10.1016/j.ijcard.2008.08.001. Epub 2008 Sep 14. Int J Cardiol. 2010. PMID: 18793814
-
Ridker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Ridker PM, et al. Circ Cardiovasc Qual Outcomes. 2009 Nov;2(6):616-23. doi: 10.1161/CIRCOUTCOMES.109.848473. Epub 2009 Sep 22. Circ Cardiovasc Qual Outcomes. 2009. PMID: 20031900 Clinical Trial.
Cited by
-
Statin Adherence: Does Gender Matter?
Goldstein KM, Zullig LL, Bastian LA, Bosworth HB. Goldstein KM, et al. Curr Atheroscler Rep. 2016 Nov;18(11):63. doi: 10.1007/s11883-016-0619-9. Curr Atheroscler Rep. 2016. PMID: 27696318 Review.
-
Challenges in Optimizing Lipid Management in Women.
Peterson KA, Kaur G, Gianos E, Mookherjee S, Poli KA, Sidhu MS, Lyubarova R. Peterson KA, et al. Cardiovasc Drugs Ther. 2022 Dec;36(6):1197-1220. doi: 10.1007/s10557-021-07273-0. Epub 2021 Oct 18. Cardiovasc Drugs Ther. 2022. PMID: 34661802 Review.
-
Predictors of cardiovascular risk in women.
Sallam T, Watson KE. Sallam T, et al. Womens Health (Lond). 2013 Sep;9(5):491-8. doi: 10.2217/whe.13.44. Womens Health (Lond). 2013. PMID: 24007254 Free PMC article. Review.
-
Perrone V, Medea G, Urbinati S, Sangiorgi D, Esposti LD; Healthcare bodies group. Perrone V, et al. Glob Reg Health Technol Assess. 2024 Jun 11;11:138-147. doi: 10.33393/grhta.2024.2731. eCollection 2024 Jan-Dec. Glob Reg Health Technol Assess. 2024. PMID: 38872910 Free PMC article. Italian.
-
Assessing and Modifying Coronary Artery Disease Risk in Women.
Sarma A, Scott NS. Sarma A, et al. Curr Treat Options Cardiovasc Med. 2017 Jul;19(7):51. doi: 10.1007/s11936-017-0554-2. Curr Treat Options Cardiovasc Med. 2017. PMID: 28523440 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical