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Purine and pyrimidine nucleotide synthesis and metabolism - PubMed

Purine and pyrimidine nucleotide synthesis and metabolism

Barbara A Moffatt et al. Arabidopsis Book. 2002.

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Figures

Figure 1.
Figure 1.

De novo biosynthetic pathway of purine nucleotides in plants. Enzymes shown are: amido phosphoribosyltransferase, (2) GAR synthetase, (3) GAR formyl transferase, (4) FGAM synthetase, (5) AIR synthetase, (6) AIR carboxylase, (7) SAICAR synthetase, (8) adenylosuccinate lyase, (9) AICAR formyl transferase, (10) IMP cyclohydrolase, (11) SAMP synthetase, (12) adenylosuccinase, (13) IMP dehydrogenase, (14) GMP synthetase.

Figure 2.
Figure 2.

De novo biosynthetic pathway of pyrimidine nucleotides in plants. Enzymes shown are: (1) Carbamoyl phosphate synthetase, (2) aspartate transcarbamoylase, (3) dihydroorotase, (4) dihydroorotate dehydrogenase, (5)-(6) UMP synthase (orotate phosphoribosyltransferase plus orotidine-5′-phosphate decarboxylase), (7) UMP kinase, (8) nucleoside diphosphate kinase, (9) CTP synthetase.

Figure 3.
Figure 3.

Salvage reactions of purine bases and nucleosides in plants. Enzymes shown are: (1) adenine phosphoribosyltransferase, (2) adenosine phosphorylase, (3) adenosine kinase, (4) adenosine phosphorylase, (5) nucleoside nucleosidase, (6) inosine-guanosine phosphorylase, (7) inosine-guanosine kinase, (8) hypoxanthine-guanine phoshoribosyltransferase. Solid arrows: major reactions; dashed arrows: minor reactions.

Figure 4.
Figure 4.

Pyrimidine salvage and related pathways in plants. Enzymes shown are: (1) Uracil phosphoribosyltransferase, (2) uridine phosphorylase, (3) uridine kinase, (4) nucleoside phosphotransferase, (5) deoxycytidine kinase, (6) thymidine kinase, (7) cytidine deaminase, (8) uridine nucleosidase. Solid arrows: major reactions; dashed arrows: minor reactions.

Figure 5.
Figure 5.

Catabolism of purine nucleotides in plants. Enzymes shown are: (1) AMP deaminase, (2) IMP dehydrogenase, (3) 5′-nucleotidase, (4) inosine-guanosine nucleosidase, (5) guanosine deaminase, (6) guanine deaminase, (7) xanthine dehydrogenase, (8) uricase, (9) allantoinase, (10) allantoicase, (11) ureidoglycolate lyase, (12) urease, (13) allantoin deaminase, (14) ureidoglycine amidohydrolase, (15) ureidoglycolate hydrolase.

Figure 6.
Figure 6.

Catabolism of pyrimidine nucleotides in plants. Enzymes shown are: (1) 5′-nucleotidase, (2) cytidine deaminase, (3) uridine nucleosidase, (4) dihydrouracil dehydrogenase, (5) dihydropyriminase, (6) b-ureidopropionase.

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References

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