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Behavioral genetics in larval zebrafish: learning from the young - PubMed

Review

Behavioral genetics in larval zebrafish: learning from the young

Marc Wolman et al. Dev Neurobiol. 2012 Mar.

Abstract

Deciphering the genetic code that determines how the vertebrate nervous system assembles into neural circuits that ultimately control behavior is a fascinating and challenging question in modern neurobiology. Because of the complexity of this problem, successful strategies require a simple yet focused experimental approach without limiting the scope of the discovery. Unbiased, large-scale forward genetic screens in invertebrate organisms have yielded great insight into the genetic regulation of neural circuit assembly and function. For many reasons, this highly successful approach has been difficult to recapitulate in the behavioral neuroscience field's classic vertebrate model organisms-rodents. Here, we discuss how larval zebrafish provide a promising model system to which we can apply the design of invertebrate behavior-based screens to reveal the genetic mechanisms critical for neural circuit assembly and function in vertebrates.

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References

1. Acevedo-Arozena A, Wells S, Potter P, Kelly M, Cox RD, Brown SD. 2008. ENU mutagenesis, a way forward to understand gene function. Annu Rev Genomics Hum Genet 9:49–69. - PubMed
1. Baier H, Scott EK. 2009. Genetic and optical targeting of neural circuits and behavior—Zebrafish in the spotlight. Curr Opin Neurobiol 19:553–560. - PMC - PubMed
1. Best JD, Berghmans S, Hunt JJ, Clarke SC, Fleming A, Goldsmith P, Roach AG. 2008. Non-associative learning in larval zebrafish. Neuropsychopharmacology 33:1206–1215. - PubMed
1. Borla MA, Palecek B, Budick S, O’Malley DM. 2002. Prey capture by larval zebrafish: Evidence for fine axial motor control. Brain Behav Evol 60:207–229. - PubMed
1. Braff DL, Geyer MA. 1990. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181–188. - PubMed

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Behavioral genetics in larval zebrafish: learning from the young - PubMed