The measles virus N(TAIL)-XD complex: an illustrative example of fuzziness - PubMed

Review

The measles virus N(TAIL)-XD complex: an illustrative example of fuzziness

Sonia Longhi. Adv Exp Med Biol. 2012.

Abstract

In this chapter, I focus on the biochemical and structural characterization of the complex between the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TAIL)) and the C-terminal X domain (XD) of the viral phosphoprotein (P). I summarize the main experimental data available so far pointing out the prevalently disordered nature of N(TAIL) even after complex formation and the role of the flexible C-terminal appendage in the binding reaction. I finally discuss the possible functional role of these residual disordered regions within the complex in terms of their ability to capture other regulatory, binding partners.

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