Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex - PubMed

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• PMID: 22442486
• DOI: 10.1126/science.1217139

Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex

Sarah Melzer et al. Science. 2012.

Abstract

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.

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