A different genetic code in human mitochondria - PubMed

• PMID: 226894
• DOI: 10.1038/282189a0

A different genetic code in human mitochondria

B G Barrell et al. Nature. 1979.

Abstract

Comparison of the human mitochrondial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of the corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon and suggests that AUA may be a methionine and not an isoleucine codon. The cytochrome oxidase II gene is contiguous at its 5' end with a tRNAAsp gene and there are only 25 bases at its 3' end before a tRNALys gene. These tRNA'S are different from all other known tRNA sequences.

Similar articles

• The genetic code in bovine mitochondria: sequence of genes for the cytochrome oxidase subunit II and two tRNAs.

  Young IG, Anderson S. Young IG, et al. Gene. 1980 Dec;12(3-4):257-65. doi: 10.1016/0378-1119(80)90108-0. Gene. 1980. PMID: 6265319

• Use of the UGA terminator as a tryptophan codon in yeast mitochondria.

  Macino G, Coruzzi G, Nobrega FG, Li M, Tzagoloff A. Macino G, et al. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3784-5. doi: 10.1073/pnas.76.8.3784. Proc Natl Acad Sci U S A. 1979. PMID: 226981 Free PMC article.

• The complete nucleotide sequence, gene organization, and genetic code of the mitochondrial genome of Paracentrotus lividus.

  Cantatore P, Roberti M, Rainaldi G, Gadaleta MN, Saccone C. Cantatore P, et al. J Biol Chem. 1989 Jul 5;264(19):10965-75. J Biol Chem. 1989. PMID: 2544576

• Convergent evolution of AUA decoding in bacteria and archaea.

  Suzuki T, Numata T. Suzuki T, et al. RNA Biol. 2014;11(12):1586-96. doi: 10.4161/15476286.2014.992281. RNA Biol. 2014. PMID: 25629511 Free PMC article. Review.

• Recent evidence for evolution of the genetic code.

  Osawa S, Jukes TH, Watanabe K, Muto A. Osawa S, et al. Microbiol Rev. 1992 Mar;56(1):229-64. doi: 10.1128/mr.56.1.229-264.1992. Microbiol Rev. 1992. PMID: 1579111 Free PMC article. Review.

Cited by

• GC-Content of Synonymous Codons Profoundly Influences Amino Acid Usage.

  Li J, Zhou J, Wu Y, Yang S, Tian D. Li J, et al. G3 (Bethesda). 2015 Aug 6;5(10):2027-36. doi: 10.1534/g3.115.019877. G3 (Bethesda). 2015. PMID: 26248983 Free PMC article.

• Mitonuclear Interactions in the Maintenance of Mitochondrial Integrity.

  Karakaidos P, Rampias T. Karakaidos P, et al. Life (Basel). 2020 Aug 31;10(9):173. doi: 10.3390/life10090173. Life (Basel). 2020. PMID: 32878185 Free PMC article. Review.

• Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma.

  Jang SC, Crescitelli R, Cvjetkovic A, Belgrano V, Olofsson Bagge R, Sundfeldt K, Ochiya T, Kalluri R, Lötvall J. Jang SC, et al. J Extracell Vesicles. 2019 Aug 27;8(1):1635420. doi: 10.1080/20013078.2019.1635420. eCollection 2019. J Extracell Vesicles. 2019. PMID: 31497264 Free PMC article.

• The mitochondrial RNA landscape of Saccharomyces cerevisiae.

  Turk EM, Das V, Seibert RD, Andrulis ED. Turk EM, et al. PLoS One. 2013 Oct 15;8(10):e78105. doi: 10.1371/journal.pone.0078105. eCollection 2013. PLoS One. 2013. PMID: 24143261 Free PMC article.

• Interactions in cytochrome oxidase: functions and structure.

  Freedman JA, Chan SH. Freedman JA, et al. J Bioenerg Biomembr. 1984 Apr;16(2):75-100. doi: 10.1007/BF00743042. J Bioenerg Biomembr. 1984. PMID: 6100297 Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource