The aryl hydrocarbon receptor system - PubMed

Review

The aryl hydrocarbon receptor system

Robert Barouki et al. Drug Metabol Drug Interact. 2012.

Abstract

The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. Recent evidence suggests that this receptor also has important endogenous functions subsequent to activation by natural dietary compounds and/or endogenous metabolites. This receptor, thus, has physiological functions that extend beyond specific instances of detoxification. Understanding the roles played by this receptor might be enhanced by a systems biology approach. Indeed, the AhR "ligandome" is very complex and the different classes of ligands involved could induce widely diverse effects. The protein "interactome" of the AhR comprises several tens of proteins and it is altered by the binding of ligands to the receptor. Furthermore, large-scale studies have shown cell and tissue-specific patterns of regulated gene expression which may depend upon the type of ligand, although these aspects need further substantiation. Finally, the AhR biological effects are extensive and include detoxification, cellular proliferation and migration, immune regulation and neuronal effects. A holistic approach should provide a better understanding of the biology of this receptor in addition to providing new avenues for the identification of specific toxicity mechanisms.

Similar articles

• An introduction to the molecular basics of aryl hydrocarbon receptor biology.

  Abel J, Haarmann-Stemmann T. Abel J, et al. Biol Chem. 2010 Nov;391(11):1235-48. doi: 10.1515/BC.2010.128. Biol Chem. 2010. PMID: 20868221 Review.

• The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein.

  Barouki R, Coumoul X, Fernandez-Salguero PM. Barouki R, et al. FEBS Lett. 2007 Jul 31;581(19):3608-15. doi: 10.1016/j.febslet.2007.03.046. Epub 2007 Mar 30. FEBS Lett. 2007. PMID: 17412325 Review.

• [Regulatory mechanism of genes by the Ah receptor which mediates toxic effects of dioxins].

  Sogawa K. Sogawa K. Nihon Rinsho. 2000 Dec;58(12):2446-51. Nihon Rinsho. 2000. PMID: 11187735 Review. Japanese.

• Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells.

  Schreck I, Chudziak D, Schneider S, Seidel A, Platt KL, Oesch F, Weiss C. Schreck I, et al. Toxicology. 2009 May 17;259(3):91-6. doi: 10.1016/j.tox.2009.02.006. Epub 2009 Feb 28. Toxicology. 2009. PMID: 19428948

• Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling.

  de Oliveira SK, Smolenski A. de Oliveira SK, et al. Biochem Pharmacol. 2009 Feb 15;77(4):723-33. doi: 10.1016/j.bcp.2008.08.027. Epub 2008 Aug 31. Biochem Pharmacol. 2009. PMID: 18805402 Review.

Cited by

• The Aryl Hydrocarbon Receptor and the Nervous System.

  Juricek L, Coumoul X. Juricek L, et al. Int J Mol Sci. 2018 Aug 24;19(9):2504. doi: 10.3390/ijms19092504. Int J Mol Sci. 2018. PMID: 30149528 Free PMC article. Review.

• In utero dioxin exposure and cardiometabolic risk in the Seveso Second Generation Study.

  Warner M, Rauch S, Ames J, Mocarelli P, Brambilla P, Signorini S, Eskenazi B. Warner M, et al. Int J Obes (Lond). 2019 Nov;43(11):2233-2243. doi: 10.1038/s41366-018-0306-8. Epub 2019 Jan 18. Int J Obes (Lond). 2019. PMID: 30659254 Free PMC article.

• Modulation of the Gut Microbiota by Resistant Starch as a Treatment of Chronic Kidney Diseases: Evidence of Efficacy and Mechanistic Insights.

  Snelson M, Kellow NJ, Coughlan MT. Snelson M, et al. Adv Nutr. 2019 Mar 1;10(2):303-320. doi: 10.1093/advances/nmy068. Adv Nutr. 2019. PMID: 30668615 Free PMC article. Review.

• AHR is a master regulator of diverse pathways in endogenous metabolism.

  Granados JC, Falah K, Koo I, Morgan EW, Perdew GH, Patterson AD, Jamshidi N, Nigam SK. Granados JC, et al. Sci Rep. 2022 Oct 5;12(1):16625. doi: 10.1038/s41598-022-20572-2. Sci Rep. 2022. PMID: 36198709 Free PMC article.

• Does air pollution play a role in infertility?: a systematic review.

  Carré J, Gatimel N, Moreau J, Parinaud J, Léandri R. Carré J, et al. Environ Health. 2017 Jul 28;16(1):82. doi: 10.1186/s12940-017-0291-8. Environ Health. 2017. PMID: 28754128 Free PMC article. Review.

Publication types

MeSH terms

Substances