pubmed.ncbi.nlm.nih.gov

Celiac disease: advances in treatment via gluten modification - PubMed

Review

Celiac disease: advances in treatment via gluten modification

Samantha Stoven et al. Clin Gastroenterol Hepatol. 2012 Aug.

Abstract

Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals carrying the prerequisite genetic markers HLA DQ2 or DQ8. These genetic markers are present in approximately 30% of the population, and the worldwide prevalence of CD is estimated to be approximately 1%-2%. Currently a gluten-free diet is the only treatment for CD, but novel therapies aimed at gluten modification are underway. This review will discuss gluten-based therapies including wheat alternatives and wheat selection, enzymatic alteration of wheat, oral enzyme supplements, and polymeric binders as exciting new therapies for treatment of CD.

Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

PubMed Disclaimer

Figures

Figure 1
Figure 1

Depicted on the left side are the four categories in which gluten can be modified: A) gluten removal via wheat mutagenesis B) Enzymatic Pretreatment of Wheat Flour C) Oral Enzyme Supplements and D) Polymeric Binders. Depicted on the right are the points in the pathogenesis of celiac disease that these four categories would act.

Similar articles

Cited by

References

    1. van den Broeck HC, et al. Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines. BMC plant biology. 2009;9:41. - PMC - PubMed
    1. Frisoni M, et al. Wheat deficient in gliadins: promising tool for treatment of coeliac disease. Gut. 1995;36(3):375–8. - PMC - PubMed
    1. Carroccio A, et al. Searching for wheat plants with low toxicity in celiac disease: Between direct toxicity and immunologic activation. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2011;43(1):34–9. - PubMed
    1. Spaenij-Dekking L, et al. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology. 2005;129(3):797–806. - PubMed
    1. Tye-Din JA, et al. The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clinical immunology. 2010;134(3):289–95. - PubMed

Publication types

MeSH terms

Substances