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Polydimethylsiloxane: a new contrast material for localization of occult breast lesions - PubMed

Polydimethylsiloxane: a new contrast material for localization of occult breast lesions

Geraldo Sérgio Farinazzo Vitral et al. Radiol Oncol. 2011 Sep.

Abstract

Background: The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of (99m)Tc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL. MATERIALS AND METHODS.: The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis.

Results: We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p <0.001). PDMS did not interfere with the scintigraphic uptake (p = 0.528) and there was no injury in histological processing of samples.

Conclusions: This study demonstrated not only the superiority of PDMS as radiological contrast in relation to the iodinated contrast, but also the technical feasibility for the same applicability in the ROLL.

Keywords: ROLL technique; breast cancer; radiological contrast; surgery.

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Figures

FIGURE 1
FIGURE 1

Representative images of heart (A), liver (B) and kidney (C) tissues from animals of all groups stained by hematoxylin-eosin. Sections of these tissues were fixed and stained with hematoxylin-eosin (HE) and examined by light microscopy (magnification: 100×). Numbers represent experimental groups (controls: 1 – absolute and 2 – relative; PDMS-treated animals: 3 - Day 1, 4 - day 7 and, 5 - day 14).

FIGURE 2
FIGURE 2

Radiological imaging of a specimen of human breast tissue marked with (A) iodinated contrast and (B) polydimethylsiloxane. Samples were sectioned at 3 cm of diameter and presented at the same degree of magnification.

FIGURE 3
FIGURE 3

Human breast tissue histology of polydimethylsiloxane (A) and iodinated contrast groups (B). Sections of human breast tissue were fixed and stained with hematoxylin-eosin (HE) and examined by light microscopy (magnification: 100×).

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