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A within-subject ERP and fMRI investigation of orientation-specific recognition memory for pictures - PubMed

  • ️Sun Jan 01 2012

A within-subject ERP and fMRI investigation of orientation-specific recognition memory for pictures

Grit Herzmann et al. Cogn Neurosci. 2012.

Abstract

Despite a large body of recognition memory research, its temporal, measured with ERPs, and spatial, measured with fMRI, substrates have never been investigated in the same subjects. In the present study, we obtained this information in parallel sessions, in which subjects studied and recognized images of visual objects and their orientation. The results showed that ERP-familiarity processes between 240 and 440 ms temporally preceded recollection processes and were structurally associated with prefrontal brain regions. Recollection processes were most prominent from 440 to 600 ms and correlated with activation in temporal, parietal, and occipital brain regions. Post-retrieval monitoring, which occurred in the ERP between 600 and 1000 ms as a long-lasting slow-wave over frontal channel groups, showed correlations with activation in the prefrontal and parietal cortex. These ERP/fMRI relationships showed some correspondences to source localizations of the investigated ERP memory effects.

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Figures

Figure 1
Figure 1

Schematic of the procedure for the ERP and fMRI sessions illustrating study list, test list, memory judgment, and experimental condition.

Figure 2
Figure 2

Geodesic sensor net layout. Electrode sites are numbered. Red clusters are regions of interest included in analyses. FPM =frontal polar medial, LAS = left anterior superior, RAS = right anterior superior, CM = central medial, LPS = left posterior superior, RPS = right posterior superior.

Figure 3
Figure 3

Average ERP waveforms for original[correct], mirror[correct], old[incorrect], and correct rejection for the FN400 (FPM, LAS, RAS, 260–440 ms), parietal old/new effect (CM, LPS, RPS, 440–600 ms), and late frontal old/new effect (FPM, LAS, RAS, 600–1000 ms).Vertical lines indicate time segments used for statistical analysis.

Figure 4
Figure 4

Voltage maps of ERP old/new effects showing the FN400 260–440 ms, the parietal old/new effect at 440–600 ms, and the late frontal old/new effect at 600–1000 ms. Spherical spline interpolation was used. Asterisks denote maps that were not associated with significant differences between conditions.

Figure 5
Figure 5

Positive (red) and negative (blue) contrasts of group activation maps (Z > 3.29, FWE α < 0.05, cluster size > 50) for the familiarity contrast (old[incorrect] > correct rejection).

Figure 6
Figure 6

Positive (red) and negative (blue) contrasts of group activation maps (Z > 3.29, FWE α < 0.05, cluster size > 50) for the contrast indicating the recollection of original images (original[correct] > old[incorrect]).

Figure 7
Figure 7

Positive (red) and negative (blue) contrasts of group activation maps (Z > 3.29, FWE α < 0.05, cluster size > 50) for the contrast indicating the recollection of mirror images (mirror[correct] > old[incorrect]).

Figure 8
Figure 8

Positive (red) and negative (blue) contrasts of group activation maps (Z > 3.29, FWE α < 0.05, cluster size > 50) for the recollection-contrast between original and mirror images (original[correct] > mirror[correct]).

Figure 9
Figure 9

ERP/fMRI relationships for the FN400 (260–440 ms) of original minus new images and the fMRI contrast of original > new images (Z > 2.58, FWE α < 0.05, cluster size > 50). For more information on significant clusters see Table 7. Blue indicates negative contrasts.

Figure 10
Figure 10

ERP/fMRI relationships for the parietal old/new effect (440–600 ms) of original minus new images and the fMRI contrast of original > new images (Z > 2.58, FWE α < 0.05, cluster size > 50). For more information on significant clusters see Table 8. Red indicates positive contrasts.

Figure 11
Figure 11

ERP/fMRI relationships for the parietal old/new effect (440–600 ms) of mirror minus new images and the fMRI contrast of mirror > new images (Z > 2.58, FWE α < 0.05, cluster size > 50). For more information on significant clusters see Table 8. Red indicates positive contrasts.

Figure 12
Figure 12

Comparison of activation patterns derived by sLORETA in GeoSource using the sLORETA option (top) and ERP/fMRI relationships (bottom) at similar axial slices (z-value in MNI space) for the recollection difference (440–600 ms) between original and mirror images, highlighting possible source generators in the occipital cortex. Source solutions were calculated for the grand mean ERP difference between original minus mirror images. ERP/fMRI relationships are red for original > mirror and blue for mirror > original (see also Table 8).

Figure 13
Figure 13

ERP/fMRI relationships for the late frontal old/new effect (600–1000 ms) of original minus new images and the fMRI contrast of original > new images (Z > 2.58, FWE α < 0.05, cluster size > 50). For more information on significant clusters see Table 9. Blue indicates negative contrasts.

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