The role of the podocyte in albumin filtration - PubMed
Review
The role of the podocyte in albumin filtration
Paul Thomas Brinkkoetter et al. Nat Rev Nephrol. 2013 Jun.
Abstract
In the past decade, our understanding of the role of podocytes in the function of the glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of proteinuric kidney disease, has substantially increased. Landmark genetic studies identified mutations in genes expressed by podocytes as a cause of albuminuria and nephrotic syndrome, leading to breakthrough discoveries from many laboratories. These discoveries contributed to a dramatic change in our view of the glomerular filtration barrier of the kidney and of the role of podocyte injury in the development of albuminuria and progressive kidney disease. In the past several years, studies have demonstrated that podocyte injury is a major cause of marked albuminuria and nephrotic syndrome, and have confirmed that podocytes are important for the maintenance of an intact glomerular filtration barrier. An essential role of loss of these cells in the pathogenesis of glomerulosclerosis and progressive proteinuric kidney disease has also been identified. In this Review, we discuss the importance of podocytes for the maintenance of an intact glomerular filtration barrier and their role in albumin handling.
Similar articles
-
Boi R, Bergwall L, Ebefors K, Bergö MO, Nyström J, Buvall L. Boi R, et al. J Am Soc Nephrol. 2023 Apr 1;34(4):641-655. doi: 10.1681/ASN.0000000000000062. Epub 2023 Jan 13. J Am Soc Nephrol. 2023. PMID: 36735952 Free PMC article.
-
Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease.
Tian X, Ishibe S. Tian X, et al. Nephrol Dial Transplant. 2016 Oct;31(10):1577-83. doi: 10.1093/ndt/gfw021. Epub 2016 Mar 10. Nephrol Dial Transplant. 2016. PMID: 26968197 Free PMC article. Review.
-
Novel routes of albumin passage across the glomerular filtration barrier.
Castrop H, Schießl IM. Castrop H, et al. Acta Physiol (Oxf). 2017 Mar;219(3):544-553. doi: 10.1111/apha.12760. Epub 2016 Aug 8. Acta Physiol (Oxf). 2017. PMID: 27452481 Review.
-
Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.
Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. Tian X, et al. J Clin Invest. 2014 Mar;124(3):1098-113. doi: 10.1172/JCI69778. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531545 Free PMC article.
-
Reply: podocytes are key-although albumin never reaches the slit diaphragm.
Moeller MJ, Tanner GA. Moeller MJ, et al. Nat Rev Nephrol. 2014 Mar;10(3):180. doi: 10.1038/nrneph.2013.58-c2. Epub 2014 Jan 28. Nat Rev Nephrol. 2014. PMID: 24468773 No abstract available.
Cited by
-
CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease.
Talyan S, Filipów S, Ignarski M, Smieszek M, Chen H, Kühne L, Butt L, Göbel H, Hoyer-Allo KJR, Koehler FC, Altmüller J, Brinkkötter P, Schermer B, Benzing T, Kann M, Müller RU, Dieterich C. Talyan S, et al. Cells. 2021 Mar 20;10(3):692. doi: 10.3390/cells10030692. Cells. 2021. PMID: 33804736 Free PMC article.
-
Najafian B, Tøndel C, Svarstad E, Sokolovkiy A, Smith K, Mauer M. Najafian B, et al. PLoS One. 2016 Apr 15;11(4):e0152812. doi: 10.1371/journal.pone.0152812. eCollection 2016. PLoS One. 2016. PMID: 27081853 Free PMC article. Clinical Trial.
-
He Y, Zhang M, Wu Y, Jiang H, Fu H, Cai Y, Xu Z, Liu C, Chen B, Yang T. He Y, et al. Cell Death Dis. 2018 Sep 20;9(10):950. doi: 10.1038/s41419-018-0985-z. Cell Death Dis. 2018. PMID: 30237561 Free PMC article.
-
Renoprotective effects of Gushen Jiedu capsule on diabetic nephropathy in rats.
Zhang L, Yang Z, Zhao Y, Yang X, Meng X, Liu J, Liu Y, Yan C, Yan D. Zhang L, et al. Sci Rep. 2020 Feb 6;10(1):2040. doi: 10.1038/s41598-020-58781-2. Sci Rep. 2020. PMID: 32029775 Free PMC article.
-
Zhang L, Chen XP, Qin H, Jiang L, Qin YH. Zhang L, et al. Ren Fail. 2018 Nov;40(1):266-272. doi: 10.1080/0886022X.2018.1456459. Ren Fail. 2018. PMID: 29619864 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous