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Prospects for oral replicating adenovirus-vectored vaccines - PubMed

  • ️Tue Jan 01 2013

Review

Prospects for oral replicating adenovirus-vectored vaccines

Cailin Deal et al. Vaccine. 2013.

Abstract

Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immunization against other infectious diseases, including those that have been refractory to traditional vaccination methods. Live rAds can express intact antigens from free-standing transgenes during replication in infected cells. Alternatively, antigenic epitopes can be displayed on the rAd capsid itself, allowing presentation of the epitope to the immune system both prior to and during replication of the virus. Such capsid-display rAds offer a novel vaccine approach that could be used either independently of or in combination with transgene expression strategies to provide a new tool in the search for protection from infectious disease.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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Conflict of interest statement

Conflict of Interest The authors have no competing financial interests to declare.

Figures

Figure 1
Figure 1

Adenovirus Capsid Structure A) Cartoon diagram of an adenovirus particle depicting capsid proteins and DNA. B) Surface model of the trimeric Ad5 hexon protein showing the HVR regions. The amino acid location of the region is located in parenthesis. Blue: HVR1 (137–181), red: HVR2 (187–193), yellow: HVR3 (211–218), green: HVR4 (247–260), purple: HVR5 (267–282), brown HVR6 (304–315), orange: HVR7 (418–428), pink: HVR8 (435–436), cyan: HVR9 (440–451). Produced using program PYMOL and PDB 3IYN [97]. C) Surface model of the trimeric Ad2 penton knob and shaft. Red: FG loop (488–515), blue: HI loop (537–549), green: IJ loop (558–572). Produced using program PYMOL and PDB 1QIU [98]. D) Map of the Ad5 hexon protein with labeled HVRs E) Map of the fiber protein with labeled β-strands in black boxes and FG, HI and IJ loops indicated with colored arrows

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