The calcium-sensing receptor directly regulates proximal tubular functions - PubMed
Comment
The calcium-sensing receptor directly regulates proximal tubular functions
Carsten A Wagner. Kidney Int. 2013 Aug.
Free article
Abstract
Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.
Comment on
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The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule.
Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. Capasso G, et al. Kidney Int. 2013 Aug;84(2):277-84. doi: 10.1038/ki.2013.137. Epub 2013 Apr 24. Kidney Int. 2013. PMID: 23615500
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