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Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant - PubMed

. 2013 Nov-Dec;121(11-12):1313-8.

doi: 10.1289/ehp.1306615. Epub 2013 Sep 5.

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Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant

Vaughn Barry et al. Environ Health Perspect. 2013 Nov-Dec.

Abstract

Background: Perfluorooctanoic acid (PFOA) is a synthetic chemical ubiquitous in the serum of U.S. residents. It causes liver, testicular, and pancreatic tumors in rats. Human studies are sparse.

Objective: We examined cancer incidence in Mid-Ohio Valley residents exposed to PFOA in drinking water due to chemical plant emissions.

Methods: The cohort consisted of adult community residents who resided in contaminated water districts or worked at a local chemical plant. Most participated in a 2005-2006 baseline survey in which serum PFOA was measured. We interviewed the cohort in 2008-2011 to obtain further medical history. Retrospective yearly PFOA serum concentrations were estimated for each participant from 1952 through 2011. Self-reported cancers were validated through medical records and cancer registry review. We estimated the association between cancer and cumulative PFOA serum concentration using proportional hazards models.

Results: Participants (n = 32,254) reported 2,507 validated cancers (21 different cancer types). Estimated cumulative serum PFOA concentrations were positively associated with kidney and testicular cancer [hazard ratio (HR) = 1.10; 95% CI: 0.98, 1.24 and HR = 1.34; 95% CI: 1.00, 1.79, respectively, for 1-unit increases in ln-transformed serum PFOA]. Categorical analyses also indicated positive trends with increasing exposures for both cancers: for kidney cancer HRs for increasing exposure quartiles were 1.0, 1.23, 1.48, and 1.58 (linear trend test p = 0.18) and for testicular cancer, HRs were 1.0, 1.04, 1.91, 3.17 (linear trend test p = 0.04).

Conclusions: PFOA exposure was associated with kidney and testicular cancer in this population. Because this is largely a survivor cohort, findings must be interpreted with caution, especially for highly fatal cancers such as pancreatic and lung cancer.

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Conflict of interest statement

The authors declare they have no actual or potential competing financial interests.

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Figure 1

Cohort enrollment.

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References

    1. Armstrong BG. Effect of measurement error on epidemiological studies of environmental and occupational exposures. Occup Environ Med. 1998;55(10):651–656. - PMC - PubMed
    1. Bergmann MM, Calle EE, Mervis CA, Miracle-McMahill HL. Validity of self-reported cancers in a prospective cohort study in comparison with data from state cancer registries. Am J Epidemiol. 1998;147(6):556–562. - PubMed
    1. Biegel LB, Hurtt ME, Frame SR, O’Connor JC, Cook JC. Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicol Sci. 2001;60(1):44–55. - PubMed
    1. Bonefeld-Jorgensen EC, Long M, Bossi R, Ayotte P, Asmond G, Krüger T, et al. 2011Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study. Environ Health 1088; 10.1186/1476-069X-10-88 - DOI - PMC - PubMed
    1. Butenhoff J, Costa G, Elcombe C, Farrar D, Hansen K, Iwai H, et al. Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. Toxicol Sci. 2002;69(1):244–257. - PubMed

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