Signaling roadmap modulating naive and primed pluripotency - PubMed

Affiliations

• PMID: 24147644
• DOI: 10.1089/scd.2013.0368

Review

Signaling roadmap modulating naive and primed pluripotency

Seyedeh-Nafiseh Hassani et al. Stem Cells Dev. 2014.

Abstract

Human and mouse embryonic stem cells (ESCs) exhibit fundamental differences depicting two distinct states of pluripotency: naive and primed. Mouse ESCs (mESCs) are dependent on leukemia inhibitory factor for growth in culture and possess two active X chromosomes in their female cell lines and correspond to the naive state of pluripotency. Human ESCs (hESCs), however, closely resemble mouse epiblast stem cells and correspond to the primed state. Primed stem cells are dependent on basic FGF for growth and show differentiation bias into different cell lineages. Recent studies have revealed that these two pluripotent states can be interconverted by modifying the culture conditions, although unequivocal evidence for obtaining truly naive hESCs has not been found. Accurate identification of the functions of major pluripotency-related signaling pathways and their cross-talk networks should aid in the successful induction of stable naive pluripotency in human cells.

Similar articles

• Mouse primed embryonic stem cells could be maintained and reprogrammed on human amnion epithelial cells.

  Chen YF, Dong Z, Jiang L, Lai D, Guo L. Chen YF, et al. Stem Cells Dev. 2013 Jan 15;22(2):320-9. doi: 10.1089/scd.2012.0325. Epub 2012 Nov 7. Stem Cells Dev. 2013. PMID: 22985337

• Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors.

  Maruotti J, Muñoz M, Degrelle SA, Gómez E, Louet C, Díez C, de Longchamp PH, Brochard V, Hue I, Caamaño JN, Jouneau A. Maruotti J, et al. Mol Reprod Dev. 2012 Jul;79(7):461-77. doi: 10.1002/mrd.22051. Epub 2012 May 31. Mol Reprod Dev. 2012. PMID: 22573702

• Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.

  Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker RC, Heijmans BT, Deforce D, De Sutter P, De Sousa Lopes SC, Heindryckx B. Duggal G, et al. Stem Cells. 2015 Sep;33(9):2686-98. doi: 10.1002/stem.2071. Epub 2015 Jun 24. Stem Cells. 2015. PMID: 26108678

• Signal regulators of human naïve pluripotency.

  Taei A, Rasooli P, Braun T, Hassani SN, Baharvand H. Taei A, et al. Exp Cell Res. 2020 Apr 15;389(2):111924. doi: 10.1016/j.yexcr.2020.111924. Epub 2020 Feb 26. Exp Cell Res. 2020. PMID: 32112799 Review.

• Pluripotent states of human embryonic stem cells.

  Chen Y, Lai D. Chen Y, et al. Cell Reprogram. 2015 Feb;17(1):1-6. doi: 10.1089/cell.2014.0061. Epub 2014 Nov 13. Cell Reprogram. 2015. PMID: 25393391 Free PMC article. Review.

Cited by

• Mechanisms of Embryonic Stem Cell Pluripotency Maintenance and Their Application in Livestock and Poultry Breeding.

  Wang Z, Gong W, Yao Z, Jin K, Niu Y, Li B, Zuo Q. Wang Z, et al. Animals (Basel). 2024 Jun 9;14(12):1742. doi: 10.3390/ani14121742. Animals (Basel). 2024. PMID: 38929361 Free PMC article. Review.

• Molecular mechanisms of induced pluripotency.

  Kulcenty K, Wróblewska J, Mazurek S, Liszewska E, Jaworski J. Kulcenty K, et al. Contemp Oncol (Pozn). 2015;19(1A):A22-9. doi: 10.5114/wo.2014.47134. Contemp Oncol (Pozn). 2015. PMID: 25691818 Free PMC article. Review.

• Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.

  Xu Z, Robitaille AM, Berndt JD, Davidson KC, Fischer KA, Mathieu J, Potter JC, Ruohola-Baker H, Moon RT. Xu Z, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6382-E6390. doi: 10.1073/pnas.1613849113. Epub 2016 Oct 3. Proc Natl Acad Sci U S A. 2016. PMID: 27698112 Free PMC article.

• From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis.

  Parfitt DE, Shen MM. Parfitt DE, et al. Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657):20130542. doi: 10.1098/rstb.2013.0542. Philos Trans R Soc Lond B Biol Sci. 2014. PMID: 25349451 Free PMC article. Review.

• Acquisition and maintenance of pluripotency are influenced by fibroblast growth factor, leukemia inhibitory factor, and 2i in bovine-induced pluripotent stem cells.

  Botigelli RC, Pieri NCG, Bessi BW, Machado LS, Bridi A, de Souza AF, Recchia K, Neto PF, Ross PJ, Bressan FF, Nogueira MFG. Botigelli RC, et al. Front Cell Dev Biol. 2022 Sep 14;10:938709. doi: 10.3389/fcell.2022.938709. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36187479 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations