pubmed.ncbi.nlm.nih.gov

Calcium permeability of ligand-gated Ca2+ channels - PubMed

  • ️Wed Jan 01 2014

Review

Calcium permeability of ligand-gated Ca2+ channels

Yuriy Pankratov et al. Eur J Pharmacol. 2014.

Abstract

Many of cation-permeable ionotropic receptors to various neurotransmitters, such as glutamate, acetylcholine and ATP, are permeable to Ca(2+) ions. For some of them, in particular NMDA, nicotinic Ach and P2X receptors, permeability to Ca(2+) is higher than permeability to monovalent cations. Such receptors can be viewed as ligand-gated Ca(2+)-channels (LGCCs). This review provides an overview of past works on structure LGCCs, including structural motifs responsible for their interaction with Ca(2+) ions, and functional implications of their Ca(2+)-permeability. The NMDA, P2X and nicotinic Ach receptors are abundantly expressed in the central nervous system. They are present at the nerve terminals, postsynaptic, extrasynaptic and glial membrane and therefore can contribute to synaptic function at different levels. Their heteromeric structure leads to wide variety of LGCC subtypes and great diversity of their functional properties. The influx of Ca(2+) provided by LGCCs can activate a plethora of secondary messenger cascades, which can modulate activity, trafficking and lateral mobility of LGCCs and thereby are entangled with their physiological function. In the discussion of the physiological importance of LGCCs we are focusing on emerging evidence on their role in control of synaptic transmission, plasticity and glia-neuron interaction.

Keywords: Ca(2+)-signalling; CaMKII; Calcium permeability; Calmodulin; Glia–neuron interaction; GluN3 subunit; Lateral diffusion; NMDA receptor; Neurotransmitter release; Nicotinic receptor; P2X receptor; PKC; Presynaptic receptor; Synaptic plasticity; Trafficking; VILIP1.

© 2013 Published by Elsevier B.V.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources