Mitochondrial and postmitochondrial survival signaling in cancer - PubMed

Review

Mitochondrial and postmitochondrial survival signaling in cancer

Neelu Yadav et al. Mitochondrion. 2014 May.

Abstract

Cancer cells are resistant to conventional chemotherapy and radiotherapy, however, the molecular mechanisms of resistance to therapy remain unclear. Cellular survival machinery protects mitochondrial integrity against endogenous or exogenous stresses. Prodeath molecules orchestrate around mitochondria to initiate and execute cell death in cancer, and also play an underappreciated role in survival of cancer cells. Prosurvival mechanisms can operate at mitochondrial and postmitochondrial levels to attenuate core apoptotic death program. It is intriguing to explore how prosurvival and prodeath molecules crosstalk to regulate mitochondrial functions leading to increased cancer cell survival. This review describes some putative survival mechanisms at mitochondria, which may play a role in designing effective agents for cancer prevention and therapy. These survival pathways may also have significance in understanding other human pathophysiological conditions including diabetes, cardiovascular, autoimmune, and neurodegenerative diseases.

Keywords: Apoptosis; Apoptosome; Electron transport chain; Mitochondria; Survival signaling; Voltage-dependent anion channel.

Similar articles

• The mitochondrial voltage-dependent anion channel 1 in tumor cells.

  Shoshan-Barmatz V, Ben-Hail D, Admoni L, Krelin Y, Tripathi SS. Shoshan-Barmatz V, et al. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2547-75. doi: 10.1016/j.bbamem.2014.10.040. Epub 2014 Nov 4. Biochim Biophys Acta. 2015. PMID: 25448878 Review.

• Oxidative phosphorylation in cancer cells.

  Solaini G, Sgarbi G, Baracca A. Solaini G, et al. Biochim Biophys Acta. 2011 Jun;1807(6):534-42. doi: 10.1016/j.bbabio.2010.09.003. Epub 2010 Sep 16. Biochim Biophys Acta. 2011. PMID: 20849810 Review.

• Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents.

  Ralph SJ, Low P, Dong L, Lawen A, Neuzil J. Ralph SJ, et al. Recent Pat Anticancer Drug Discov. 2006 Nov;1(3):327-46. doi: 10.2174/157489206778776952. Recent Pat Anticancer Drug Discov. 2006. PMID: 18221044 Review.

• VDAC, a multi-functional mitochondrial protein regulating cell life and death.

  Shoshan-Barmatz V, De Pinto V, Zweckstetter M, Raviv Z, Keinan N, Arbel N. Shoshan-Barmatz V, et al. Mol Aspects Med. 2010 Jun;31(3):227-85. doi: 10.1016/j.mam.2010.03.002. Epub 2010 Mar 23. Mol Aspects Med. 2010. PMID: 20346371 Review.

• [The use of flow cytometry for analysis of the mitochondrial cell death].

  Pekarčíková L, Knopfová L, Ondroušková E, Smarda J. Pekarčíková L, et al. Klin Onkol. 2014;27 Suppl 1:S15-21. doi: 10.14735/amko20141s15. Klin Onkol. 2014. PMID: 24945532 Czech.

Cited by

• Administration of Ketamine Causes Autophagy and Apoptosis in the Rat Fetal Hippocampus and in PC12 Cells.

  Li X, Li Y, Zhao J, Li L, Wang Y, Zhang Y, Li Y, Chen Y, Liu W, Gao L. Li X, et al. Front Cell Neurosci. 2018 Feb 2;12:21. doi: 10.3389/fncel.2018.00021. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29456493 Free PMC article.

• Neem components as potential agents for cancer prevention and treatment.

  Hao F, Kumar S, Yadav N, Chandra D. Hao F, et al. Biochim Biophys Acta. 2014 Aug;1846(1):247-57. doi: 10.1016/j.bbcan.2014.07.002. Epub 2014 Jul 10. Biochim Biophys Acta. 2014. PMID: 25016141 Free PMC article. Review.

• Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPR^ER) and Beyond.

  Rahman S, Kumar V, Kumar A, Abdullah TS, Rather IA, Jan AT. Rahman S, et al. Biomedicines. 2021 Jun 2;9(6):635. doi: 10.3390/biomedicines9060635. Biomedicines. 2021. PMID: 34199484 Free PMC article. Review.

• Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.

  Luo C, DU Z, Wei X, Chen G, Fu Z. Luo C, et al. Oncol Lett. 2015 Jan;9(1):270-274. doi: 10.3892/ol.2014.2685. Epub 2014 Nov 7. Oncol Lett. 2015. PMID: 25435973 Free PMC article.

• Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.

  Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D. Hardonnière K, et al. Sci Rep. 2017 Mar 15;7(1):195. doi: 10.1038/s41598-017-00269-7. Sci Rep. 2017. PMID: 28298645 Free PMC article.

References

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • scite Smart Citations