pubmed.ncbi.nlm.nih.gov

Role of the tumor microenvironment in the pathogenesis of gastric carcinoma - PubMed

️Wed Jan 01 2014

Review

Role of the tumor microenvironment in the pathogenesis of gastric carcinoma

Hye Won Chung et al. World J Gastroenterol. 2014.

Abstract

Gastric carcinoma (GC) is the 4(th) most prevalent cancer and has the 2(nd) highest cancer-related mortality rate worldwide. Despite the incidence of GC has decreased over the past few decades, it is still a serious health problem. Chronic inflammatory status of the stomach, caused by the infection of Helicobacter pylori (H. pylori) and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC. In this review, the correlation between chronic inflammation and H. pylori infection as an important factor for the development of GC will be discussed. Major components, including tumor-associated macrophages, lymphocytes, cancer-associated fibroblasts, angiogenic factors, cytokines, and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed. Increasing our understanding of how the components of the tumor microenvironment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.

Keywords: Cytokine; Gastric carcinoma; Helicobacter pylori; Inflammation; Tumor microenvironment.

PubMed Disclaimer

Cited by

Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo.
Zibara K, Awada Z, Dib L, El-Saghir J, Al-Ghadban S, Ibrik A, El-Zein N, El-Sabban M. Zibara K, et al. Sci Rep. 2015 Jul 28;5:12598. doi: 10.1038/srep12598. Sci Rep. 2015. PMID: 26218768 Free PMC article.
Evaluation of thymic stromal lymphopoietin (TSLP) and its correlation with lymphatic metastasis in human gastric cancer.
Barooei R, Mahmoudian RA, Abbaszadegan MR, Mansouri A, Gholamin M. Barooei R, et al. Med Oncol. 2015 Aug;32(8):217. doi: 10.1007/s12032-015-0653-4. Epub 2015 Jul 15. Med Oncol. 2015. PMID: 26175262
Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer.
de Oliveira JG, Rossi AF, Nizato DM, Cadamuro AC, Jorge YC, Valsechi MC, Venâncio LP, Rahal P, Pavarino ÉC, Goloni-Bertollo EM, Silva AE. de Oliveira JG, et al. Tumour Biol. 2015 Dec;36(12):9159-70. doi: 10.1007/s13277-015-3593-x. Epub 2015 Jun 19. Tumour Biol. 2015. PMID: 26088449
Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature.
Yang E, Chua W, Ng W, Roberts TL. Yang E, et al. Biomedicines. 2021 Dec 14;9(12):1916. doi: 10.3390/biomedicines9121916. Biomedicines. 2021. PMID: 34944729 Free PMC article. Review.
A novel pyroptosis-related gene signature to predict outcomes in laryngeal squamous cell carcinoma.
Zhou C, Zhan G, Jin Y, Chen J, Shen Z, Shen Y, Deng H. Zhou C, et al. Aging (Albany NY). 2021 Dec 15;13(24):25960-25979. doi: 10.18632/aging.203783. Epub 2021 Dec 15. Aging (Albany NY). 2021. PMID: 34910689 Free PMC article.

References

1. Torpy JM, Lynm C, Glass RM. JAMA patient page. Stomach cancer. JAMA. 2010;303:1771. - PubMed
1. Terry MB, Gaudet MM, Gammon MD. The epidemiology of gastric cancer. Semin Radiat Oncol. 2002;12:111–127. - PubMed
1. Hohenberger P, Gretschel S. Gastric cancer. Lancet. 2003;362:305–315. - PubMed
1. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539–545. - PubMed
1. Hussain SP, Harris CC. Inflammation and cancer: an ancient link with novel potentials. Int J Cancer. 2007;121:2373–2380. - PubMed

Role of the tumor microenvironment in the pathogenesis of gastric carcinoma - PubMed