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Effects of aging on the plasma levels of nesfatin-1 and adiponectin - PubMed

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Jiang-Bo Li et al. Biomed Rep. 2014 Jan.

Abstract

Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin-1, an appetite-suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin-1 and adiponectin. Our results demonstrated no significant differences in the nesfatin-1 plasma levels among three age groups (2, 6 and 24 months) of female BALB/c mice. The plasma nesfatin-1 levels/visceral fat (VF) ratio in the 24-month-old mice was significantly lower compared to that in the 2- and 6-month-old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels/VF ratio in the 24-month-old mice was significantly lower compared to that in the 2- and 6-month-old mice. In conclusion, there were no age-related changes in the plasma levels of nesfatin-1 and adiponectin, although the ratio of plasma levels of nesfatin-1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin-1 and adiponectin may be involved in controlling energy balance during aging.

Keywords: adiponectin; aging; appetite regulation; nesfatin-1.

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Figures

Figure 1
Figure 1

(A) Plasma nesfatin-1 levels and (B) plasma nesfatin-1 level/VF ratio in female BALB/c mice aged 2, 6 and 24 months. Data are expressed as means ± standard error of the mean (SEM). **P<0.01.

Figure 2
Figure 2

(A) Plasma adiponectin levels and (B) plasma adiponectin level/VF ratio of female BALB/c mice aged 2, 6 and 24 months. Data are expressed as means ± standard error of the mean (SEM). ***P<0.001.

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References

    1. Neary NM, Goldstone AP, Bloom SR. Appetite regulation: from the gut to the hypothalamus. Clin Endocrinol (Oxf) 2004;60:153–160. - PubMed
    1. Sahu A, Kalra SP. Neuropeptidergic regulation of feeding behavior Neuropeptide Y. Trends Endocrinol Metab. 1993;4:217–224. - PubMed
    1. Wynne K, Stanley S, Bloom S. The gut and regulation of body weight. J Clin Endocrinol Metab. 2004;89:2576–2582. - PubMed
    1. Wolden-Hanson T, Marck BT, Matsumoto AM. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. Am J Physiol Regul Integr Comp Physiol. 2004;287:R138–R146. - PubMed
    1. Shklyaev S, Aslanidi G, Tennant M, et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci USA. 2003;100:14217–14222. - PMC - PubMed

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