"The race" to clone BRCA1 - PubMed

Affiliations

• PMID: 24675952
• DOI: 10.1126/science.1251900

"The race" to clone BRCA1

Mary-Claire King. Science. 2014.

Abstract

The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q21. Knowing that such a gene existed and approximately where it lay triggered efforts by public and private groups to clone and sequence it. The press baptized the competition "the race" and reported on it in detail for the next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect on "the race" and its consequences for breast cancer prevention and treatment.

Similar articles

• Linkage analysis of BRCA1 in Japanese breast cancer families.

  Inoue R, Fukutomi T, Ushijima T, Matsumoto Y, Sugimura T, Nagao M. Inoue R, et al. Jpn J Cancer Res. 1994 Dec;85(12):1233-9. doi: 10.1111/j.1349-7006.1994.tb02935.x. Jpn J Cancer Res. 1994. PMID: 7852187 Free PMC article.

• Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

  Brown MA, Jones KA, Nicolai H, Bonjardim M, Black D, McFarlane R, de Jong P, Quirk JP, Lehrach H, Solomon E. Brown MA, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4362-6. doi: 10.1073/pnas.92.10.4362. Proc Natl Acad Sci U S A. 1995. PMID: 7753812 Free PMC article.

• Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer.

  Merajver SD, Frank TS, Xu J, Pham TM, Calzone KA, Bennett-Baker P, Chamberlain J, Boyd J, Garber JE, Collins FS, et al. Merajver SD, et al. Clin Cancer Res. 1995 May;1(5):539-44. Clin Cancer Res. 1995. PMID: 9816013

• BRCA1 and BRCA2 in breast cancer.

  Yang X, Lippman ME. Yang X, et al. Breast Cancer Res Treat. 1999 Mar;54(1):1-10. doi: 10.1023/a:1006189906896. Breast Cancer Res Treat. 1999. PMID: 10369075 Review.

• Identification of the BRCA1 breast cancer gene and its clinical implications.

  Kamb A, Skolnick MH. Kamb A, et al. Important Adv Oncol. 1996:23-35. Important Adv Oncol. 1996. PMID: 8791126 Review. No abstract available.

Cited by

• PARPs in genome stability and signal transduction: implications for cancer therapy.

  Palazzo L, Ahel I. Palazzo L, et al. Biochem Soc Trans. 2018 Dec 17;46(6):1681-1695. doi: 10.1042/BST20180418. Epub 2018 Nov 12. Biochem Soc Trans. 2018. PMID: 30420415 Free PMC article. Review.

• Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.

  Chiang HC, Zhang X, Zhao X, Zhang C, Chen J, Garza P, Smith S, Ludwig T, Baer RJ, Li R, Hu Y. Chiang HC, et al. Sci Rep. 2018 Feb 9;8(1):2731. doi: 10.1038/s41598-018-21044-2. Sci Rep. 2018. PMID: 29426838 Free PMC article.

• BRCA Mutations and Fertility Preservation.

  Dias Nunes J, Demeestere I, Devos M. Dias Nunes J, et al. Int J Mol Sci. 2023 Dec 22;25(1):204. doi: 10.3390/ijms25010204. Int J Mol Sci. 2023. PMID: 38203374 Free PMC article. Review.

• Profile of Mary-Claire King, 2014 Lasker-Koshland Special Achievement in Medical Science awardee.

  Chakravarti A. Chakravarti A. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17690-2. doi: 10.1073/pnas.1418785111. Epub 2014 Nov 25. Proc Natl Acad Sci U S A. 2014. PMID: 25425662 Free PMC article. No abstract available.

• BRCAness revisited.

  Lord CJ, Ashworth A. Lord CJ, et al. Nat Rev Cancer. 2016 Feb;16(2):110-20. doi: 10.1038/nrc.2015.21. Epub 2016 Jan 18. Nat Rev Cancer. 2016. PMID: 26775620 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal