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Follicular dendritic cells: dynamic antigen libraries - PubMed

Review

. 2014 Jul;14(7):495-504.

doi: 10.1038/nri3689. Epub 2014 Jun 20.

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Review

Follicular dendritic cells: dynamic antigen libraries

Balthasar A Heesters et al. Nat Rev Immunol. 2014 Jul.

Abstract

Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the development of B cell memory. Historically, FDCs have been characterized as 'accessory' cells that passively support germinal centre (GC) responses. However, recent observations suggest that FDCs actively shape humoral immunity. In this Review, we discuss recent findings concerning the antigen acquisition and retention functions of FDCs, and relevant implications for protective immunity. Furthermore, we describe the roles of FDCs within GCs in secondary lymphoid organs and discuss FDC development within this dynamic environment. Finally, we discuss how a better understanding of FDCs could facilitate the design of next-generation vaccines.

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References

    1. Curr Opin Immunol. 2014 Jun;28:90-6 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Aug;42(2):121-30 - PubMed
    1. Immunity. 2002 Dec;17(6):823-33 - PubMed
    1. J Exp Med. 1997 Dec 15;186(12):1997-2004 - PubMed
    1. Nat Rev Immunol. 2003 Nov;3(11):867-78 - PubMed

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