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Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression: a systematic review and meta-analysis - PubMed

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Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression: a systematic review and meta-analysis

Beppe Micallef-Trigona. Depress Res Treat. 2014.

Abstract

Electroconvulsive therapy (ECT) is the longest standing psychiatric treatment available and has unequivocal benefit in severe depression. However this treatment comes with a number of side effects such as memory impairment. On the other hand, Repetitive Transcranial Magnetic Stimulation (rTMS) is a relatively new form of treatment which has been shown to be efficacious in patients suffering from a number of psychopathologies, including severe depression, with few reported side effects. Due to its potential therapeutic efficacy and lack of side effects, rTMS has gained traction in the treatment of depression, with a number of authors keen to see it take over from ECT. However, it is not clear whether rTMS represents a therapeutic alternative to ECT. This meta-analysis will therefore compare the "gold standard" treatment for severe depression, with the relatively new but promising rTMS. A literature search will be performed with the intention to include all randomised clinical trials. The null hypothesis is that there is no difference in the antidepressant efficacy between the two types of treatment modalities. Statistical analysis of Hamilton Depression Rating Scale (HDRS) scores will be performed.

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Figures

Figure 1
Figure 1

Radial Plot rTMS.

Figure 2
Figure 2

Forrest Plot rTMS.

Figure 3
Figure 3

Radial Plot ECT.

Figure 4
Figure 4

Forrest Plot ECT.

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References

    1. Pagnin D, de Queiroz V, Pini S, Cassano GB. Efficacy of ECT in depression: a meta-analytic review. The Journal of ECT. 2004;20(1):13–20. - PubMed
    1. Geddes J, Carney S, Cowen P, et al. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. The Lancet. 2003;361(9360):799–808. - PubMed
    1. Husain MM, Rush AJ, Fink M, et al. Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): a consortium for research in ECT (CORE) report. Journal of Clinical Psychiatry. 2004;65(4):485–491. - PubMed
    1. Kellner CH, Knapp RG, Petrides G. Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study. Archives of General Psychiatry. 2006;63(12):1337–1344. - PMC - PubMed
    1. Petrides G, Fink M, Husain MM, et al. ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. The Journal of ECT. 2001;17(4):244–253. - PubMed

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