Khat use and appetite: an overview and comparison of amphetamine, khat and cathinone - PubMed

Ethnopharmacological relevance: To understand the role of khat (Catha edulis) use on the aberrations in appetite and weight which are common comorbidities for khat and other amphetamine users.

Materials and methods: We provide a comprehensive overview and conceptual summary of the historical cultural use of khat as a natural stimulant and describe the similarities and differences between cathinone (the main psychoactive constituent of khat) and amphetamine highlighting the limited literature on the neurophysiology of appetite and subsequent weight effects of khat.

Results: Animal and some human studies indicate that khat produces appetite suppression, although little is known about mechanisms of this effect. Both direct and indirect effects of khat stem from multiple factors including behavioral, chemical and neurophysiological effects on appetite and metabolism. Classic and newly identified appetite hormones have not been explored sufficiently in the study of appetite and khat use. Unique methodological challenges and opportunities are encountered when examining effects of khat and cathinone including khat-specific medical comorbidities, unique route of administration, differential patterns of behavioral effects relative to amphetamines and the nascent state of our understanding of the neurobiology of this drug.

Conclusion: A considerable amount of work remains in the study of the appetite effects of khat chewing and outline a program of research that could inform our understanding of this natural amphetamine׳s appetite effects and help prepare health care workers for the unique health effects of this drug.

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• DA024626/DA/NIDA NIH HHS/United States
• R01 DA027232/DA/NIDA NIH HHS/United States
• R21 DA024626/DA/NIDA NIH HHS/United States
• R03 TW007219/TW/FIC NIH HHS/United States
• R03TW007219/TW/FIC NIH HHS/United States

• R21DA024626/DA/NIDA NIH HHS/United States