Nerve growth factor induces growth and differentiation of human B lymphocytes - PubMed

Nerve growth factor induces growth and differentiation of human B lymphocytes

U Otten et al. Proc Natl Acad Sci U S A. 1989 Dec.

Abstract

Nerve growth factor (NGF) is known to affect peripheral sympathetic and sensory neurons as well as defined populations of neurons in the central nervous system. This paper presents evidence that NGF is also active in modulation of B-cell-mediated immune responses. NGF receptors were immunoprecipitated from highly purified human B-cell populations, and to a lesser extent, from T-cell populations, by using a monoclonal antibody recognizing NGF receptors present on neural cells. NGF receptors were also detected in significant amounts in human spleen and lymph node tissue. In addition, NGF induced a dose-dependent increase in B-cell DNA synthesis as determined by incorporation of [3H]thymidine. This B-cell growth-promoting activity was inhibited by a neutralizing anti-NGF monoclonal antibody. Immunoglobulin secretion, principally affecting IgM synthesis, was also modulated by NGF. The concentrations that affected B-cell proliferation are consistent with the presence of functional high-affinity NGF receptors. The results suggest that NGF, in addition to its neurotrophic function, also acts as an immunoregulatory cytokine.

Similar articles

• Nerve growth factor specifically induces human IgG4 production.

  Kimata H, Yoshida A, Ishioka C, Kusunoki T, Hosoi S, Mikawa H. Kimata H, et al. Eur J Immunol. 1991 Jan;21(1):137-41. doi: 10.1002/eji.1830210121. Eur J Immunol. 1991. PMID: 1991484

• Nerve growth-factor and anti-CD40 provide opposite signals for the production of IgE in interleukin-4-treated lymphocytes.

  Brodie C, Oshiba A, Renz H, Bradley K, Gelfand EW. Brodie C, et al. Eur J Immunol. 1996 Jan;26(1):171-8. doi: 10.1002/eji.1830260127. Eur J Immunol. 1996. PMID: 8566063

• Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes.

  Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci-Laudiero L, Aloe L, Ferrari S, Cossarizza A, Giannetti A. Pincelli C, et al. J Invest Dermatol. 1994 Jul;103(1):13-8. doi: 10.1111/1523-1747.ep12388914. J Invest Dermatol. 1994. PMID: 8027574

• [A sensitive two-site (sandwich) enzyme immunoassay system for measuring nerve growth factor (NGF)].

  Furukawa S. Furukawa S. Nihon Yakurigaku Zasshi. 1997 May;109(5):235-41. doi: 10.1254/fpj.109.235. Nihon Yakurigaku Zasshi. 1997. PMID: 9211449 Review. Japanese.

• Nerve growth factor: a survey of activity on immune and hematopoietic cells.

  Simone MD, De Santis S, Vigneti E, Papa G, Amadori S, Aloe L. Simone MD, et al. Hematol Oncol. 1999 Mar;17(1):1-10. doi: 10.1002/(sici)1099-1069(199903)17:1<1::aid-hon635>3.0.co;2-l. Hematol Oncol. 1999. PMID: 10440888 Review.

Cited by

• Nerve growth factor: from the early discoveries to the potential clinical use.

  Aloe L, Rocco ML, Bianchi P, Manni L. Aloe L, et al. J Transl Med. 2012 Nov 29;10:239. doi: 10.1186/1479-5876-10-239. J Transl Med. 2012. PMID: 23190582 Free PMC article. Review.

• Association of NGF and Mitochondrial Respiration with Autism Spectrum Disorder.

  Gevezova M, Minchev D, Pacheva I, Todorova T, Yordanova R, Timova E, Ivanov I, Sarafian V. Gevezova M, et al. Int J Mol Sci. 2022 Oct 7;23(19):11917. doi: 10.3390/ijms231911917. Int J Mol Sci. 2022. PMID: 36233217 Free PMC article.

• Nerve growth factor binding sites on hepatic parenchymal cells.

  Bailie MB, Roth RA, Contreras ML. Bailie MB, et al. In Vitro Cell Dev Biol. 1992 Sep-Oct;28A(9-10):621-4. doi: 10.1007/BF02631037. In Vitro Cell Dev Biol. 1992. PMID: 1429364

• Low frequency of plasma nerve-growth factor detection is associated with death of memory B lymphocytes in HIV-1 infection.

  Titanji K, Nilsson A, Mörch C, Samuelsson A, Sönnerborg A, Grutzmeier S, Zazzi M, De Milito A. Titanji K, et al. Clin Exp Immunol. 2003 May;132(2):297-303. doi: 10.1046/j.1365-2249.2003.02145.x. Clin Exp Immunol. 2003. PMID: 12699420 Free PMC article.

• The dark side of the NGF family: neurotrophins in neoplasias.

  Krüttgen A, Schneider I, Weis J. Krüttgen A, et al. Brain Pathol. 2006 Oct;16(4):304-10. doi: 10.1111/j.1750-3639.2006.00037.x. Brain Pathol. 2006. PMID: 17107600 Free PMC article. Review.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database