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Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study - PubMed

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Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study

Kristen Lyall et al. Autism Res. 2015 Oct.

Abstract

Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors.

Keywords: allergy; asthma; autism; food allergy.

© 2015 International Society for Autism Research, Wiley Periodicals, Inc.

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Figures

Figure 1.
Figure 1.

Prevalence of maternally reported asthma and allergies in children with typical development (controls) and with ASD (cases) from the CHARGE study. Case asthma and allergy % shown in black, controls in grey. Allergy categories are not mutually exclusive. “Other allergy” refers to individuals reporting allergies not falling into the specified categories, while “multiple allergies” refers to those reporting in more than one category. Sixty-four cases (24% in cases with allergy) and 47 controls (26% in controls with allergy) did not report allergy type.

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