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Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer - PubMed

Review

Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer

Dominik D Alexander et al. Nutr Cancer. 2015.

Abstract

We conducted a systematic review and meta-analysis to estimate the potential association between LCω-3PUFAs and prostate cancer (PC). A comprehensive literature search was performed through 2013 to identify prospective studies that examined dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCω-3PUFA) or blood biomarkers of LCω-3PUFA status and risk of PC. Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade. Subgroup analyses were also conducted for specific fatty acids and other study characteristics. Twelve self-reported dietary intake and 9 biomarker studies from independent study populations were included in the analysis, with 446,243 and 14,897 total participants, respectively. No association between LCω-3PUFAs and total PC was observed (SRRE = 1.00, 95% CI: 0.93-1.09) for the dietary intake studies (high vs. low LCω-3PUFAs category comparison) or for the biomarker studies (SRRE of 1.07, 95% CI: 0.94-1.20). In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude. The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

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Figures

**FIG. 1.**
Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: dietary intake studies, overall and by follow-up duration.

**FIG. 2.**
Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: biomarker studies, overall and by follow-up duration.

**FIG. 3.**
Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer by grade: biomarker studies.

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References

1. American Cancer Society . Cancer Facts & Figures. Atlanta, GA: American Cancer Society; 2014.
1. National Cancer Institute SEER Stat Fact Sheets: Prostate Cancer: Surveillance, Epidemiology, and End Results Program. National Cancer Institute, National Institutes of Health. 2014
1. International Agency for Research on Cancer . Weight control and physical activity. In: Vainio H, Bianchini F, editors. IARC Handbook of Cancer Prevention. Lyon, France: IARC Press; 2002. http://www.iarc.fr/en/publications/pdfs-online/prev/handbook6/Handbook6.pdf
1. Morote J, Celma A, Planas J, Placer J, Konstantinidis C.Sedentarism and overweight as risk factors for the detection of prostate cancer and its aggressivenes Actas Urol Esp 382013 - PubMed
1. Murphy AB, Akereyeni F, Nyame YA, Guy MC, Martin IK. Smoking and prostate cancer in a multi-ethnic cohort. Prostate. 2013:1518–1528. - PMC - PubMed

Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer - PubMed