pubmed.ncbi.nlm.nih.gov

Evidence of altered autonomic cardiac regulation in breast cancer survivors - PubMed

Observational Study

doi: 10.1007/s11764-015-0445-z. Epub 2015 Apr 22.

Affiliations

Observational Study

Evidence of altered autonomic cardiac regulation in breast cancer survivors

Chiara Vigo et al. J Cancer Surviv. 2015 Dec.

Abstract

Purpose: Surgery and adjuvant therapy improved prognosis of breast cancer survivors. This improvement risks being offset by potential late-occurring cardiovascular toxicity of oncologic treatment and increased cardiometabolic risk profile associated with lifestyle changes. We address the hypothesis that in breast cancer survivors, multiple functional alterations might define a phenotype, characterized by vagal impairment, diminished aerobic fitness, increased metabolic risk, and reduced wellbeing.

Methods: We studied 171 sedentary asymptomatic women (106 cancer survivor-65 controls) of similar age (53 ± 8.6; 51 ± 8.1 years). Autonomic regulation was evaluated by autoregressive spectral analysis of R wave to R wave (RR) interval and systolic arterial pressure variability. Aerobic fitness was directly assessed by cardiopulmonary exercise test. Body mass index (BMI) and waist circumference served as proxies of metabolism. Fatigue and stress-related symptoms were evaluated with validated questionnaire.

Results: Patients showed significantly smaller total RR variance (1644 ± 2363 vs. 2302 ± 1561 msec2), smaller absolute power of low frequency (LF) (386 ± 745 vs. 810 ± 1300 msec2) and high frequency (HF) (485 ± 1202 vs. 582 ± 555 msec2) of RR interval variability and smaller spontaneous baroreflex sensitivity (15.0 ± 8.9 vs. 21.9 ± 10 msec/mmHg), suggesting vagal impairment. VO2 peak and O2 pulse were lower in cancer survivors than in controls. Fatigue and stress-related somatic symptoms scores were higher, as was BMI and waist circumference.

Conclusion: Breast cancer survivors show multiple dysfunctions: vagal impairment, lower aerobic fitness, signs of altered metabolism, and higher perception of fatigue.

Implications for cancer survivors: We propose that the concept of clinical phenotype, which may accommodate multiple functional disturbances, might be useful in long-term personalized prevention programs for breast cancer survivors.

Keywords: Autonomic nervous system; Baroreflex sensitivity; Cardiometabolic risk; Cardiorespiratory fitness; Lifestyle; Secondary prevention.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Eur Respir J. 2013 Jun;41(6):1252-6 - PubMed
    1. Auton Neurosci. 2012 Jan 26;166(1-2):96-9 - PubMed
    1. Lancet Oncol. 2010 Jun;11(6):596-601 - PubMed
    1. Lancet Oncol. 2012 Aug;13(8):790-801 - PubMed
    1. N Engl J Med. 2001 Jun 28;344(26):1997-2008 - PubMed

Publication types

MeSH terms

LinkOut - more resources