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The genetics of early-onset bipolar disorder: A systematic review - PubMed

  • ️Thu Jan 01 2015

Review

The genetics of early-onset bipolar disorder: A systematic review

Kevin P Kennedy et al. J Affect Disord. 2015.

Abstract

Background: Early-onset bipolar disorder has been associated with a significantly worse prognosis than late-onset BD and has been hypothesized to be a genetically homogenous subset of BD. A sizeable number of studies have investigated early-onset BD through linkage-analyses, candidate-gene association studies, genome-wide association studies (GWAS), and analyses of copy number variants (CNVs), but this literature has not yet been reviewed.

Methods: A systematic review was conducted using the PubMed database on articles published online before January 15, 2015 and after 1990. Separate searches were made for linkage studies, candidate gene-association studies, GWAS, and studies on CNVs.

Results: Seventy-three studies were included in our review. There is a lack of robust positive findings on the genetics of early-onset BD in any major molecular genetics method.

Limitations: Early-onset populations were quite small in some studies. Variance in study methods hindered efforts to interpret results or conduct meta-analysis.

Conclusions: The field is still at an early phase for research on early-onset BD. The largely null findings mirror the results of most genetics research on BD. Although most studies were underpowered, the null findings could mean that early-onset BD may not be as genetically homogenous as has been hypothesized or even that early-onset BD does not differ genetically from adult-onset BD. Nevertheless, clinically the probabilistic developmental risk trajectories associated with early-onset that may not be primarily genetically determined continued to warrant scrutiny. Future research should dramatically expand sample sizes, use atheoretical research methods like GWAS, and standardize methods.

Keywords: Bipolar disorder; Early-onset; Genetics.

Copyright © 2015. Published by Elsevier B.V.

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Conflict of interest statement

Conflict of Interest

Disclosures: The authors have no conflicts of interests to disclose. All authors have approved the final article.

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References

    1. Akiskal HS, Downs J, Jordan P, Watson S, Daugherty D, Pruitt DB. Affective disorders in referred children and younger siblings of manic-depressives: mode of onset and prospective course. Arch Gen Psychiatry. 1985;42(10):996–1003. http://dx.doi.org/10.1001/archpsyc.1985.01790330076009. - DOI - PubMed
    1. Alloy LB, Abramson LY, Walshaw PD, Keyser J, Gerstein RK. A cognitive vulnerability-stress perspective on bipolar spectrum disorders in a normative adolescent brain, cognitive, and emotional development context. Dev Psychopathol. 2006;18:1055–1103. http://dx.doi.org/10.1017/S0954579406060524. - DOI - PubMed
    1. Andreazza AC, Kauer-Sant’Anna M, Frey BN, Bond DJ, Kapczinski F, Young LT, Yatham LN. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord. 2008;111(2–3):135–144. http://dx.doi.org/10.1016/j.jad.2008.04.013. - DOI - PubMed
    1. Andreazza AC. Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders. Mol Biosyst. 2012;8:2503. http://dx.doi.org/10.1039/c2mb25118c. - DOI - PubMed
    1. Artioli P, Lorenzi C, Pirovano A, Serretti A, Benedetti F, Catalano M, Smeraldi E. How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. Eur Neuropsychopharmacol. 2007;17:587–594. http://dx.doi.org/10.1016/j.euroneuro.2007.03.004. - DOI - PubMed

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