Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk - PubMed

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Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk

Steven K Malin et al. Exerc Sport Sci Rev. 2016 Jan.

Abstract

Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.

Comment in

• Exercise Plus Metformin in the Fight Against Diabetes.

  Boulé NG. Boulé NG. Exerc Sport Sci Rev. 2016 Jan;44(1):2. doi: 10.1249/JES.0000000000000071. Exerc Sport Sci Rev. 2016. PMID: 26674094 No abstract available.

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