Predominance of DR3 in Somali children with type 1 diabetes in the twin cities, Minnesota - PubMed
. 2017 Mar;18(2):136-142.
doi: 10.1111/pedi.12369. Epub 2016 Feb 8.
Janelle A Noble 2 , Liping Yu 3 , Zahra Mahamed 1 , Julie A Lane 2 , Abdirahman M Dhunkal 1 , Melena D Bellin 1 , Brandon Nathan 1 , Jennifer Kyllo 4 , M Jennifer Abuzzahab 4 , Peter A Gottlieb 3 , Sunanda Babu 3 , Taylor Armstrong 3 , Antoinette Moran 1
Affiliations
- PMID: 26854192
- DOI: 10.1111/pedi.12369
Predominance of DR3 in Somali children with type 1 diabetes in the twin cities, Minnesota
Muna Sunni et al. Pediatr Diabetes. 2017 Mar.
Abstract
Background: Minnesota is home to the largest Somali population in USA, and pediatric diabetes teams are seeing increasing numbers of Somali children with diabetes.
Objective: To assess the immune basis of diabetes in Somali children in the Twin Cities, Minnesota.
Methods: A total of 31 Somali children ≤19 yr were treated for type 1 diabetes (T1D) at the University of Minnesota Masonic Children's Hospital and Children's Hospitals and Clinics of Minnesota underwent analysis of human leukocyte antigen (HLA) alleles (n = 30) and diabetes autoantibodies [glutamic acid decarboxylase (GAD65), islet antigen 2 (IA-2), zinc transporter 8 (ZnT8); n = 31]. HLA alleles were analyzed in 49 Somalis without diabetes (controls). Anti-transglutaminase autoantibodies (TGA) for celiac disease were also measured.
Results: In Somali children with T1D aged 13.5 ± 5 yr (35% female, disease duration 6.5 ± 3.6 yr), the most common HLA allele was DRB1*03:01 (93%, compared with 45% of Somali controls), followed by DRB1*13:02 (27%). There was a relatively low frequency of DR4 (13%). Controls showed a similar pattern. All 31 participants were positive for at least one diabetes autoantibody. Insulin antibodies were positive in 84% (all were on insulin). Excluding insulin antibodies, 23 (74%) subjects tested positive for at least one other diabetes autoantibody; 32% had 1 autoantibody, 32% had 2 autoantibodies, and 10% had 3 autoantibodies. GAD65 autoantibodies were found in 56% of subjects, IA-2 in 29%, and ZnT8 in 26%. Four (13%) were TGA positive.
Conclusion: The autoantibody and HLA profiles of Somali children with diabetes are consistent with autoimmune diabetes. Their HLA profile is unique with an exceptionally high prevalence of DRB1*03:01 allele and relative paucity of DR4 alleles compared with African Americans with T1D.
Keywords: Somali; T1D; diabetes autoimmunity; human leukocyte antigen.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
-
Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK. Kozhakhmetova A, et al. Clin Exp Immunol. 2018 Jun;192(3):251-258. doi: 10.1111/cei.13115. Epub 2018 Mar 24. Clin Exp Immunol. 2018. PMID: 29431870 Free PMC article.
-
Ferber KM, Keller E, Albert ED, Ziegler AG. Ferber KM, et al. J Clin Endocrinol Metab. 1999 Jul;84(7):2342-8. doi: 10.1210/jcem.84.7.5813. J Clin Endocrinol Metab. 1999. PMID: 10404800
-
El-Amir MI, El-Feky MA, Laine AP, Härkönen T, El-Badawy O, Eltayeb AA, El-Melegy TT, Kiviniemi M, Knip M, Ilonen J. El-Amir MI, et al. Diabetes Metab Res Rev. 2015 Mar;31(3):287-94. doi: 10.1002/dmrr.2609. Epub 2014 Nov 24. Diabetes Metab Res Rev. 2015. PMID: 25256132
-
Type 1 diabetes and autoimmunity.
Kawasaki E. Kawasaki E. Clin Pediatr Endocrinol. 2014 Oct;23(4):99-105. doi: 10.1297/cpe.23.99. Epub 2014 Nov 6. Clin Pediatr Endocrinol. 2014. PMID: 25374439 Free PMC article. Review.
-
The interplay of autoimmunity and insulin resistance in type 1 diabetes.
Nokoff NJ, Rewers M, Cree Green M. Nokoff NJ, et al. Discov Med. 2012 Feb;13(69):115-22. Discov Med. 2012. PMID: 22369970 Free PMC article. Review.
Cited by
-
Ali AA, Aalto M, Jonasson J, Osman A. Ali AA, et al. Sci Rep. 2020 Mar 27;10(1):5652. doi: 10.1038/s41598-020-62645-0. Sci Rep. 2020. PMID: 32221414 Free PMC article.
-
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.
Ibrahim TAM, Govender D, Abdullah MA, Noble JA, Hussien MO, Lane JA, Mack SJ, Martin GGN, Atkinson MA, Wasserfall CH, Ogle GD. Ibrahim TAM, et al. Pediatr Diabetes. 2021 Aug;22(5):749-757. doi: 10.1111/pedi.13209. Epub 2021 Apr 20. Pediatr Diabetes. 2021. PMID: 33837995 Free PMC article.
-
Sunni M, Kyllo J, Brunzell C, Majcozak J, Osman M, Dhunkal AM, Moran A. Sunni M, et al. J Clin Transl Endocrinol. 2023 Feb 4;31:100313. doi: 10.1016/j.jcte.2023.100313. eCollection 2023 Mar. J Clin Transl Endocrinol. 2023. PMID: 36820203 Free PMC article.
-
A picture-based carbohydrate-counting resource for Somalis.
Sunni M, Brunzell C, Kyllo J, Purcell L, Plager P, Moran A. Sunni M, et al. J Int Med Res. 2018 Jan;46(1):219-224. doi: 10.1177/0300060517718732. Epub 2017 Jul 31. J Int Med Res. 2018. PMID: 28758850 Free PMC article.
-
Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS. Redondo MJ, et al. Lancet Diabetes Endocrinol. 2022 Aug;10(8):597-608. doi: 10.1016/S2213-8587(22)00159-0. Epub 2022 Jun 17. Lancet Diabetes Endocrinol. 2022. PMID: 35724677 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials