Antioxidants and multistage carcinogenesis in mouse skin - PubMed

Review

Antioxidants and multistage carcinogenesis in mouse skin

J P Perchellet et al. Free Radic Biol Med. 1989.

Abstract

The two-step initiation-promotion protocol for the induction of skin tumors in mice is a convenient model to elucidate what molecular events are involved in the multistage process of carcinogenesis and how they can be modulated. The current theories concerning the mechanisms of skin tumor initiation, stages 1 and 2 of tumor promotion, and tumor progression are reviewed. Because chemical carcinogens and tumor promoters may, directly or indirectly, generate reactive oxygen species (ROS) and because various antioxidants inhibit effectively some of the biochemical and biological events linked to tumor initiation, promotion and/or progression, it is conceivable that different sequences and levels of free radical-induced macromolecule damage may contribute to the evolution of the epidermal target cells from the preneoplastic stage to the malignant stage.

Similar articles

• Inhibition of the induction of cancer by antioxidants.

  Slaga TJ. Slaga TJ. Adv Exp Med Biol. 1995;369:167-74. doi: 10.1007/978-1-4615-1957-7_15. Adv Exp Med Biol. 1995. PMID: 7598004 Review.

• Active oxygen species as factors in multistage carcinogenesis.

  Witz G. Witz G. Proc Soc Exp Biol Med. 1991 Nov;198(2):675-82. doi: 10.3181/00379727-198-43306. Proc Soc Exp Biol Med. 1991. PMID: 1656469 Review.

• Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds.

  Slaga TJ. Slaga TJ. Crit Rev Food Sci Nutr. 1995 Jan;35(1-2):51-7. doi: 10.1080/10408399509527686. Crit Rev Food Sci Nutr. 1995. PMID: 7748479 Review.

• Free radicals, metals and antioxidants in oxidative stress-induced cancer.

  Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Valko M, et al. Chem Biol Interact. 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. Epub 2006 Jan 23. Chem Biol Interact. 2006. PMID: 16430879 Review.

• Multistage carcinogenesis in mouse skin.

  DiGiovanni J. DiGiovanni J. Pharmacol Ther. 1992;54(1):63-128. doi: 10.1016/0163-7258(92)90051-z. Pharmacol Ther. 1992. PMID: 1528955 Review.

Cited by

• Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice.

  Vabeiryureilai M, Lalrinzuali K, Jagetia GC. Vabeiryureilai M, et al. Heliyon. 2019 Nov 1;5(10):e02521. doi: 10.1016/j.heliyon.2019.e02521. eCollection 2019 Oct. Heliyon. 2019. PMID: 31720442 Free PMC article.

• Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.

  Chibaya L, Karim B, Zhang H, Jones SN. Chibaya L, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2003193118. doi: 10.1073/pnas.2003193118. Proc Natl Acad Sci U S A. 2021. PMID: 33468664 Free PMC article.

• Modulatory effects of Crataeva nurvala bark against testosterone and N-methyl-N-nitrosourea-induced oxidative damage in prostate of male albino rats.

  Kumar DG, Deepa P, Rathi MA, Meenakshi P, Gopalakrishnan VK. Kumar DG, et al. Pharmacogn Mag. 2012 Oct;8(32):285-91. doi: 10.4103/0973-1296.103654. Pharmacogn Mag. 2012. PMID: 24082632 Free PMC article.

• Nucleolar organizer regions as a marker of incipient transformation in a model of experimental carcinogenesis.

  Carbonelli DL, Durán HA, Schwint A, Molinari de Rey B. Carbonelli DL, et al. Virchows Arch. 1994;425(2):165-70. doi: 10.1007/BF00230353. Virchows Arch. 1994. PMID: 7952501

• Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels.

  Hermenegildo C, Raya A, Romá J, Romero FJ. Hermenegildo C, et al. Neurochem Res. 1993 Aug;18(8):893-6. doi: 10.1007/BF00998274. Neurochem Res. 1993. PMID: 8396737

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information