pubmed.ncbi.nlm.nih.gov

Metformin: A Hopeful Promise in Aging Research - PubMed

  • ️Fri Jan 01 2016

Review

Metformin: A Hopeful Promise in Aging Research

Marta G Novelle et al. Cold Spring Harb Perspect Med. 2016.

Abstract

Even though the inevitable process of aging by itself cannot be considered a disease, it is directly linked to life span and is the driving force behind all age-related diseases. It is an undisputable fact that age-associated diseases are among the leading causes of death in the world, primarily in industrialized countries. During the last several years, an intensive search of antiaging treatments has led to the discovery of a variety of drugs that promote health span and/or life extension. The biguanide compound metformin is widely used for treating people with type 2 diabetes and appears to show protection against cancer, inflammation, and age-related pathologies. Here, we summarize the recent developments about metformin use in translational aging research and discuss its role as a potential geroprotector.

Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.

Summary of the effects of metformin supplementation in invertebrate (Caenorhabditis elegans and Drosophila melanogaster) and vertebrate models (rodents, mainly mice).

Similar articles

Cited by

References

    1. Adeyemo MA, McDuffie JR, Kozlosky M, Krakoff J, Calis KA, Brady SM, Yanovski JA. 2014. Effects of metformin on energy intake and satiety in obese children. Diabetes Obes Metab 17: 363–370. - PMC - PubMed
    1. Aldea M, Craciun L, Tomuleasa C, Berindan-Neagoe I, Kacso G, Florian IS, Crivii C. 2014. Repositioning metformin in cancer: Genetics, drug targets, and new ways of delivery. Tumour Biol 35: 5101–5110. - PubMed
    1. American Diabetes Association. 2014. Standards of medical care in diabetes—2014. Diabetes Care 37: S14–S80. - PubMed
    1. Anisimov VN. 2014. Do metformin a real anticarcinogen? A critical reappraisal of experimental data. Ann Transl Med 2: 60. - PMC - PubMed
    1. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, et al. 2005a. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 40: 685–693. - PubMed

Publication types

MeSH terms

Substances