pubmed.ncbi.nlm.nih.gov

Graves Disease Is Associated With Endometriosis: A 3-Year Population-Based Cross-Sectional Study - PubMed

Observational Study

Graves Disease Is Associated With Endometriosis: A 3-Year Population-Based Cross-Sectional Study

Jin-Sung Yuk et al. Medicine (Baltimore). 2016 Mar.

Abstract

The aim of this cross-sectional study was to compare the prevalence of thyroid diseases between women with and without endometriosis.We established the endometriosis group according to diagnosis codes, surgery codes, and gonadotropin-releasing hormone agonist codes using the Korean Health Insurance Review and Assessment Service-National Inpatients Sample (HIRA-NIS) from 2009 to 2011. Four controls were randomly matched to each endometriosis case. Thyroid disease cases were selected using the thyroid disease diagnosis code (E0X).Among the 1,843,451 women sampled, 5615 had endometriosis; 22,460 controls were matched to the endometriosis cases. After adjustment for age and sampling year, Graves disease was associated with endometriosis (odds ratio [OR]: 2.52; 95% CI: 1.30-4.88; P < 0.01), while hypothyroidism was not (OR: 1.17; 95% CI: 0.90-1.52; P = 0.25). Autoimmune hypothyroidism was also not associated with endometriosis (OR: 1.61; 95% CI: 0.88-2.94; P = 0.12).This study revealed an association between Graves disease and endometriosis.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1

Flow chart representing the selection procedure based on the HIRA sample from 2009 to 2011. aSurgery codes: R4122, R4160, R4165, R4166, R4170, R4181, R4182, R4183, R4331, R4332, R4341, R4342, R4345, R4421, R4430, and R4435. bGnRH agonist codes: 182602BIJ, 182604BIJ, 244902BIJ, 167202BIJ, 167201BIJ, 198501CSI, 140301ACH, and 140302ACH. GnRH = gonadotropin-releasing hormone, HIRA = Health Insurance Review and Assessment Service.

Similar articles

Cited by

References

    1. Dunselman GAJ, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014; 29:400–412. - PubMed
    1. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997; 24:235–258. - PubMed
    1. Bulun SE. Endometriosis. N Engl J Med 2009; 360:268–279. - PubMed
    1. Giudice LC, Kao LC. Endometriosis. Lancet 2004; 364:1789–1799. - PubMed
    1. Nothnick WB. Treating endometriosis as an autoimmune disease. Fertil Steril 2001; 76:223–231. - PubMed

Publication types

MeSH terms