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Risk factors and distribution of oncogenic strains of human papilloma virus in women presenting for cervical cancer screening in Port Harcourt, Nigeria - PubMed

  • ️Fri Jan 01 2016

Risk factors and distribution of oncogenic strains of human papilloma virus in women presenting for cervical cancer screening in Port Harcourt, Nigeria

Nyengidiki Tamunomie Kennedy et al. Pan Afr Med J. 2016.

Abstract

Introduction: Human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) genotypes largely responsible. The objective is to ascertain the distribution of oncogenic strains of human papilloma virus genotypes and predisposing risk factors in women presenting for cervical cancer screening in Nigeria.

Methods: A cross-sectional study of 80 women who presented for cervical cancer screening. The biodata of the participants, the presence of risk factors to HPV were recorded and hrHPV were identified using PCR technique. The information obtained was processed using the SPSS version 20 software. Results were presented in tables, test of significance and association done using student's t-test and Odds ratio, with P value < 0.05 as significant.

Results: The age range of patients was 19-62 years with prevalence of hrHPV of 10%. HrHPV are more in patients with more than one life time sexual partner (OR 1.26,95%CI 0.13-29.99), multiple sexual partners (OR 1.55, 95% CI 0.28-8.70), early coitarche (OR 1.57, 95% CI 0.14-15.00) and previous STI (OR 150, 95%CI 9.53-1979. 62). Four hrHPV genotypes: 16, 18, 31 and 35 were detected.

Conclusion: HPV genotype 18 was predominant in Port Harcourt, Nigeria. High risk sexual behaviours are associated with acquisition of hrHPV.

Keywords: HPV; Nigeria; Port Harcourt; prevalence; risk factors.

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References

    1. Anorlu RI. Tumours of the cervix. In: Akin Agboola., editor. Textbook of Obstetrics and Gynaecology for medical students. 2nd edition. Ibadan: Heinemann educational books; 2006. pp. 167–182.
    1. Parkin DM, Bray F. The burden of HPV-related cancers. Vaccine. 2006;24(3):S11–S25. - PubMed
    1. Hernandez BU, Wickens LR, Zhu X. Transmission of HPV in heterosexual couples. Emerg Infect Dis. 2008 Jun;14(6):888–894. - PMC - PubMed
    1. Thomas JO, Herrero R, Omigbodun AA, Oje-Makinde K, Ajayi OI, Fawole A, et al. Prevalence of Papillomavirus infection in Ibadan, Nigeria: a population-based study. Br J Cancer. 2004 Feb 9;90(3):638–645. - PMC - PubMed
    1. Chinchai Y, Chanaaenroj J, Swangvarees T, Junyagdkul P, Poovarawan Y. Prevalence of HPV genotypes in cervical cancer. Int J Gynaecol cancer. 2012;22(6):1063–1068. - PubMed

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