pubmed.ncbi.nlm.nih.gov

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence - PubMed

  • ️Fri Jan 01 2016

Review

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

Ritesh Kotecha et al. Oncotarget. 2016.

Abstract

Cancer chemoprevention involves the use of different natural or biologic agents to inhibit or reverse tumor growth. Epidemiological and pre-clinical data suggest that various natural phytochemicals and dietary compounds possess chemopreventive properties, and in-vitro and animal studies support that these compounds may modulate signaling pathways involved in cell proliferation and apoptosis in transformed cells, enhance the host immune system and sensitize malignant cells to cytotoxic agents. Despite promising results from experimental studies, only a limited number of these compounds have been tested in clinical trials and have shown variable results. In this review, we summarize the data regarding select phytochemicals including curcumin, resveratrol, lycopene, folates and tea polyphenols with emphasis on the clinical evidence supporting the efficacy of these compounds in high-risk populations.

Keywords: antioxidants; cancer chemoprevention; curcumin; phytochemicals; resveratrol.

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interest to declare.

Figures

Figure 1
Figure 1. Carcinogenesis is a multistep process that ultimately reprogram a normal cell into a cancer cell

Phytochemicals may exert their chemopreventive effects by blocking key events of tumor initiation and promotion thus reversing the premalignant stage. These agents may also prevent tumorigenesis by inhibiting or retarding tumor progression or by promoting cell differentiation.

Similar articles

Cited by

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. Aleksandrova K, Pischon T, Jenab M, Bueno-de-Mesquita HB, Fedirko V, Norat T, Romaguera D, Knüppel S, Boutron-Ruault MC, Dossus L, Dartois L, Kaaks R, Li K, et al. Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study. BMC Med. 2014;12:168. - PMC - PubMed
    1. Garcia DO, Thomson CA. Physical activity and cancer survivorship. Nutr Clin Pract. 2014;29:768–79. - PMC - PubMed
    1. Mehta M, Shike M. Diet and physical activity in the prevention of colorectal cancer. J Natl Compr Canc Netw. 2014;12:1721–6. - PubMed
    1. Howes MJ, Simmonds MS. The role of phytochemicals as micronutrients in health and disease. Curr Opin Clin Nutr Metab Care. 2014;17:558–66. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources