Pre-exposure prophylaxis for HIV infection and new sexually transmitted infections among men who have sex with men - PubMed

Meta-Analysis

Pre-exposure prophylaxis for HIV infection and new sexually transmitted infections among men who have sex with men

Noah Kojima et al. AIDS. 2016.

Abstract

We conducted a meta-analysis to summarize rates of sexually transmitted infections among men who have sex with men (MSM) on pre-exposure prophylaxis (PrEP) for HIV versus MSM not using PrEP. Incidence rate ratios showed that MSM using PrEP were 25.3 times more likely to acquire a Neisseria gonorrhoeae infection, 11.2 times more likely to acquire a Chlamydia trachomatis infection, and 44.6 times more likely to acquire a syphilis infection versus MSM not using PrEP.

Comment in

• Serious concerns regarding a meta-analysis of preexposure prophylaxis use and STI acquisition.

  Harawa NT, Holloway IW, Leibowitz A, Weiss R, Gildner J, Landovitz RJ, Perez MJ, Kulkarni S, Rotheram-Borus MJ, Shoptaw S. Harawa NT, et al. AIDS. 2017 Mar 13;31(5):739-740. doi: 10.1097/QAD.0000000000001386. AIDS. 2017. PMID: 28225452 Free PMC article. No abstract available.

• Addressing concerns regarding preexposure prophylaxis meta-analysis.

  Kojima N, Davey DJ, Klausner JD. Kojima N, et al. AIDS. 2017 Mar 13;31(5):740-742. doi: 10.1097/QAD.0000000000001375. AIDS. 2017. PMID: 28225453 No abstract available.

• Limitations of using the Lorenz curve framework to understand the distribution of population viral load.

  Tsai AC. Tsai AC. AIDS. 2017 Mar 13;31(5):742. doi: 10.1097/QAD.0000000000001388. AIDS. 2017. PMID: 28225454 Free PMC article. No abstract available.

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