Novel functions of Fanconi anemia proteins in selective autophagy and inflammation - PubMed
- ️Fri Jan 01 2016
Editorial
Novel functions of Fanconi anemia proteins in selective autophagy and inflammation
Rhea Sumpter et al. Oncotarget. 2016.
No abstract available
Keywords: BRCA; Fanconi anemia; inflammasome; innate immunity; mitophagy.
Figures
In a wild-type cells (left panels), viruses and damaged mitochondria are targeted by selective autophagy. This process removes pro-inflammatory pathogenassociated molecular patterns (PAMPs; e.g. viral nucleic acids) and danger associated molecular patterns (DAMPs; e.g. mitochondrial (mt) ROS). Defective clearance of selective autophagy substrates in FA gene-deficient cells (right panels) results in persistence of PAMPs and DAMPs, increased inflammasome activation, and oxidative genotoxic stress.
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