pubmed.ncbi.nlm.nih.gov

Interventions for men and women with their first episode of genital herpes - PubMed

  • ️Fri Jan 01 2016

References to studies included in this review

Adams 1976 {published data only}
    1. Adams HG, Benson EA, Alexander ER, Vontver LA, Remington MA, Holmes KK. Genital herpetic infection in men and women: clinical course and effect of topical application of adenine arabinoside. Journal of Infectious Diseases 1976;133(Suppl):A151‐9. - PubMed
    1. Adams HG, Benson EA, Alexander ER, Vontver LA, Remington MA, Holmes KK. Genital herpetic infection in men and women: clinical course and effect of topical application of adenine arabinoside [abstract]. British Journal of Venereal Diseases 1977;53(2):152. - PubMed
Altomare 1985 {published data only}
    1. Altomare GF, Polenghi MM, Pigatto PD, Oberhauser V. Tromantadine hydrochlorate in the treatment of genital herpes. A double blind controlled clinical trial. Giornale Italiano di Dermatologia e Venereologia 1985;120(4):XLI‐VI. - PubMed
Batcheler 1986 {published data only}
    1. Batcheler LM, Bonham DG, Collins R, Liddell HS. Topical interferon cream for the treatment of herpes genitalis: a double‐blind controlled trial. Australian & New Zealand Journal of Obstetrics & Gynaecology 1986;26(3):239‐41. - PubMed
Bryson 1983 {published data only (unpublished sought but not used)}
    1. Bryson Y, Dillon M, Lovett M, Bernstein D, Garratty E, Sayre J. Treatment of first episode genital HSV with oral acyclovir: long term follow‐up of recurrences. A preliminary report. Scandinavian Journal of Infectious Diseases Supplement 1985;47:70‐5. - PubMed
    1. Bryson YJ, Dillon M, Lovett M. Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir: a randomised double‐blind control study trial in normal patients [abstract]. British Journal of Venereal Diseases 1983;59(5):346. - PubMed
    1. Bryson YJ, Dillon M, Lovett M, Acuna G, Taylor S, Cherry JD, et al. Successful treatment of initial genital herpes simplex virus infections with oral acyclovir [abstract]. Clinical Research 1982;30:128A.
    1. Bryson YJ, Dillon M, Lovett M, Acuna G, Taylor S, Cherry JD, et al. Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double‐blind controlled trial in normal subjects. New England Journal of Medicine 1983;308(16):916‐21. - PubMed
Corey 1982a {published data only}
    1. Corey L, Nahmias AJ, Guinan ME, Benedetti JK, Critchlow CW, Holmes KK. A trial of topical acyclovir in genital herpes simplex virus infections. New England Journal of Medicine 1982;306(22):1313‐9. - PubMed
    1. Lafferty WE, Brewer LA, Corey L. Alteration of lymphocyte transformation response to herpes simplex virus infection by acyclovir therapy. Antimicrobial Agents and Chemotherapy 1984;26(6):887‐91. - PMC - PubMed
Corey 1982b {published data only (unpublished sought but not used)}
    1. Corey L, Benedetti JK, Critchlow CW, Remington MR, Winter CA, Fahnlander AL. Double‐blind controlled trial of topical acyclovir in genital herpes simplex virus infections. American Journal of Medicine 1982;73(1A):326‐34. - PubMed
    1. Lafferty WE, Brewer LA, Corey L. Alteration of lymphocyte transformation response to herpes simplex virus infection by acyclovir therapy. Antimicrobial Agents and Chemotherapy 1984;26(6):887‐91. - PMC - PubMed
Corey 1983 {published data only (unpublished sought but not used)}
    1. Corey L, Fife KH, Benedetti JK, Winter CA, Fahnlander A, Connor JD. Intravenous acyclovir for the treatment of primary genital herpes. Annals of Internal Medicine 1983;98(6):914‐21. - PubMed
    1. Corey L, Mindel A, Fife KH, Sutherland S, Benedetti J, Adler MW. Risk of recurrence after treatment of first‐episode genital herpes with intravenous acyclovir. Sexually Transmitted Diseases 1985;12(4):215‐8. - PubMed
    1. Lafferty WE, Brewer LA, Corey L. Alteration of lymphocyte transformation response to herpes simplex virus infection by acyclovir therapy. Antimicrobial Agents and Chemotherapy 1984;26(6):887‐91. - PMC - PubMed
Csonka 1984 {published data only}
    1. Csonka GW, Tyrrell DA. Treatment of herpes genitalis with carbenoxolone and cicloxolone creams: a double blind placebo controlled clinical trial. British Journal of Venereal Diseases 1984 Jun;60(3):178‐81. - PMC - PubMed
Fiddian 1983 {published data only (unpublished sought but not used)}
    1. Barton IG, Kinghorn GR, Rowland M, Jeavons M, Al‐Omer LS, Potter CW. Recurrences after first episodes of genital herpes in patients treated with topical acyclovir cream. Antiviral Research 1984;4(5):293‐300. - PubMed
    1. Fiddian AP, Kinghorn GR, Goldmeier D, Rees E, Rodin P, Thin RNT, et al. Topical acyclovir in the treatment of genital herpes ‐ a comparison with systemic therapy. Journal of Antimicrobial Chemotherapy 1983;12:67‐77. - PubMed
    1. Kinghorn GR, Turner EB, Barton IG, Potter CW, Burke CA, Fiddian AP. Efficacy of topical acyclovir cream in first and recurrent episodes of genital herpes. Antiviral Research 1983;3(5‐6):291‐301. - PubMed
    1. Thin RN, Nabarro JM, Parker JD, Fiddian AP. Topical acyclovir in the treatment of initial genital herpes. British Journal of Venereal Diseases 1983;59(2):116‐9. - PMC - PubMed
Fife 1997 {published data only (unpublished sought but not used)}
    1. Fife KH, Barbarash RA, Rudolph T, Degregorio B, Roth R, The Valaciclovir International Herpes Simplex Virus Study Group. Valaciclovir versus acyclovir in the treatment of first‐episode genital herpes infection: results of an international, multicenter, double‐blind, randomized clinical trial. Sexually Transmitted Diseases 1997;24(8):481‐6. - PubMed
Kinghorn 1986a {published data only (unpublished sought but not used)}
    1. Kinghorn GR, Abeywickreme I, Jeavons M, Barton I, Potter CW, Jones D, et al. Efficacy of combined treatment with oral and topical acyclovir in first episode genital herpes. Genitourinary Medicine 1986;62(3):186‐8. - PMC - PubMed
Kinghorn 1986b {published data only (unpublished sought but not used)}
    1. Kinghorn GR, Abeywickreme I, Jeavons M, Rowland M, Barton I, Al‐Hasani G, et al. Efficacy of oral treatment with acyclovir and co‐trimoxazole in first episode genital herpes. Genitourinary Medicine 1986;62(1):33‐7. - PMC - PubMed
Lai 2000 {published data only}
    1. Lai WH. Valaciclovir hydrochloride versus aciclovir in the treatment of first‐episode genital herpes: a controlled, randomized open trial [Chinese]. Chinese Journal of Dermatovenereology 2000;14(1):34‐6.
Levin 1989 {published data only (unpublished sought but not used)}
    1. Levin MJ, Judson FN, Eron L, Bryson YJ, Corey L, Murray M, et al. Comparison of intramuscular recombinant alpha interferon (rIFN‐2A) with topical acyclovir for the treatment of first‐episode herpes genitalis and prevention of recurrences. Antimicrobial Agents and Chemotherapy 1989;33(5):649‐52. - PMC - PubMed
Mendelson 1986 {published data only}
    1. Mendelson J, Clecner B, Eiley S. Effect of recombinant interferon alpha 2 on clinical course of first episode genital herpes infection and subsequent recurrences. Genitourinary Medicine 1986;62(2):97‐101. - PMC - PubMed
Mertz 1984 {published data only (unpublished sought but not used)}
    1. Loveless M, Sacks SL, Harris JRW. Famciclovir in the management of first‐episode genital herpes. Infectious Diseases in Clinical Practice 1997;6(Suppl 1):12‐6.
    1. Mertz GJ. Clinical study of a new antiherpes drug: long‐term follow‐up of patients with primary genital herpes infection treated by oral acyclovir therapy: the frequency of recurrence of genital herpes. Therapeutic Research 1985;2(4):652‐4.
    1. Mertz GJ, Critchlow CW, Benedetti J. Double‐blind placebo‐controlled trial or oral acyclovir in first‐episode genital herpes simplex virus infection. JAMA 1984;252(9):1147‐51. - PubMed
Mindel 1982 {published data only}
    1. Corey L, Mindel A, Fife KH, Sutherland S, Benedetti J, Adler MW. Risk of recurrence after treatment of first‐episode genital herpes with intravenous acyclovir. Sexually Transmitted Diseases 1985;12(4):215‐8. - PubMed
    1. Mindel A, Adler MW, Sutherland S, Fiddian AP. Intravenous acyclovir in genital herpes. An interim report. American Journal of Medicine 1982;73(1A):347‐50. - PubMed
    1. Mindel A, Adler MW, Sutherland S, Fiddian AP. Intravenous acyclovir treatment for primary genital herpes. Lancet 1982;1(8274):697‐700. - PubMed
Mindel 1986 {published data only (unpublished sought but not used)}
    1. Mindel A, Weller IV, Faherty A, Sutherland S, Fiddian AP, Adler MW. Acyclovir in first attacks of genital herpes and prevention of recurrences. Genitourinary Medicine 1986;62(1):28‐32. - PMC - PubMed
Mindel 1987 {published data only (unpublished sought but not used)}
    1. Mindel A. Comparative studies of inosine pranobex and acyclovir. American Journal of Medicine 1988;85(2A):7‐9. - PubMed
    1. Mindel A, Kinghorn G, Allason‐Jones E, Woolley P, Barton I, Faherty A, et al. Treatment of first‐attack genital herpes‐‐acyclovir versus inosine pranobex. Lancet 1987;1(8543):1171‐3. - PubMed
Niimura 1996 {published data only}
    1. Niimura M, Kobayashi T, Kumamoto Y, Kumazawa J, Kawashima M, Honda M, et al. Clinical efficacy of famciclovir on Herpes Simplex virus infection: double‐blind, dose ranging study. Rinsho Iyaku [Journal of Clinical Therapeutics and Medicines] 1996;12(16):3567‐95.
Nilsen 1982 {published data only (unpublished sought but not used)}
    1. Fiddian AP, Halsos AM, Kinge BR. Oral acyclovir in the treatment of genital herpes: preliminary report of a multicenter trial [abstract]. British Journal of Venereal Diseases 1983;59(2):142. - PubMed
    1. Fiddian AP, Halsos AM, Kinge BR, Nilsen AE, Wikstrom K. Oral acyclovir in the treatment of genital herpes. Preliminary report of a multicenter trial. American Journal of Medicine 1982;73(1A):335‐7. - PubMed
    1. Loveless M, Sacks SL, Harris JRW. Famciclovir in the management of first‐episode genital herpes. Infectious Diseases in Clinical Practice 1997;6(Suppl 1):12‐6.
    1. Nilsen AE, Aasen T, Halsos AM, Kinge BR, Tjotta EA, Wikstrom K, et al. Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes. Lancet 1982;2(8298):571‐3. - PubMed
Pazin 1987 {published data only}
    1. Pazin GJ, Harger JH, Armstrong JA, Breinig MK, Caplan RJ, Cantell K, et al. Leukocyte interferon for treating first episodes of genital herpes in women. Journal of Infectious Diseases 1987;156(6):891‐8. - PMC - PubMed
Peacock 1988 {published data only (unpublished sought but not used)}
    1. Peacock JE. Intravenous acyclovir therapy of first episodes of genital herpes ‐ a multicenter double‐blind, placebo‐controlled trial [abstract]. Genitourinary Medicine 1989;65(2):137. - PubMed
    1. Peacock JE, Kaplowitz Jr LG, Sparling PF, Durack DT, Gnann Jr JW, Whitley RJ, et al. Intravenous acyclovir therapy of first episodes of genital herpes: a multicenter double‐blind, placebo‐controlled trial. American Journal of Medicine 1988;85(3):301‐6. - PubMed
Silvestri 1982 {published data only}
    1. Silvestri DL, Corey L, Holmes KK. Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes. JAMA 1982;248(8):953‐9. - PubMed
Wald 1994 {published data only (unpublished sought but not used)}
    1. Wald A, Benedetti J, Davis G, Remington M, Winter C, Corey L. A randomized, double‐blind, comparative trial comparing high‐ and standard‐dose oral acyclovir for first‐episode genital herpes infections. Antimicrobial Agents and Chemotherapy 1994;38(2):174‐6. - PMC - PubMed
Zavala 1988 {published data only}
    1. Zavala Trujillo I, Garibay Valencia M, Fortuno Cordova V. Treatment of genital herpes with ribavirin. Investigacion Medica Internacional 1988;15(4):202‐9.

References to studies excluded from this review

Al‐Hasani 1986 {published data only}
    1. Al‐Hasani AM, Barton IG, Al‐Omer LS, Kinghorn GR, Potter CW. Susceptibility of HSV strains from patients with genital herpes treated with various formulations of acyclovir. Journal of Antimicrobial Chemotherapy 1986;18(Suppl B):113‐9. - PubMed
Anonymous 1985 {published data only}
    1. Anonymous. Oral acyclovir for genital herpes simplex infection. Medical Letter on Drugs and Therapeutics 1985;27(687):41‐3. - PubMed
Anonymous 1997 {published data only}
    1. Anonymous. Trial will determine how treating patient's first genital herpes outbreak with famciclovir will eliminate future outbreaks. AIDS Patient Care and STDs 1997;11(4):294‐5.
Anonymous 2004 {published data only}
    1. Anonymous. Antiviral drug reduces herpes transmission. Pharmaceutical Journal 2004;272(7282):44.
Armstrong 1983 {published data only}
    1. Armstrong JA, Skicki‐Mullen MB, Breinig MK, Ho M. Interferon susceptibility of herpes simplex virus strains isolated from patients enrolled in clinical trials. Antimicrobial Agents and Chemotherapy 1983;24(1):137‐9. - PMC - PubMed
Ashley 1984 {published data only}
    1. Ashley RL, Corey L. Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus. Journal of Clinical Investigation 1984;73(3):681‐8. - PMC - PubMed
Ashley 1988 {published data only}
    1. Ashley R, Mack K, Critchlow C, Shurtleff M, Corey L. Differential effect of systemic acyclovir treatment of genital HSV‐2 infections on antibody responses to individual HSV‐2 proteins. Journal of Medical Virology 1988;24(3):309‐19. - PubMed
Baeten 2008 {published data only}
    1. Baeten JM, Strick LB, Lucchetti A, Whittington WLH, Sanchez J, Coombs RW, et al. Herpes simplex virus (HSV)‐suppressive therapy decreases plasma and genital HIV‐1 levels in HSV‐2/HIV‐1 coinfected women: a randomized, placebo‐controlled, cross‐over trial. Journal of Infectious Diseases 2008;198(12):1804‐8. - PMC - PubMed
Balfour 1994 {published data only}
    1. Balfour Jr HH, Benson C, Braun J, Cassens B, Erice A, Friedman‐Kien A, et al. Management of acyclovir‐resistant herpes simplex and varicella‐zoster virus infections. Journal of Acquired Immune Deficiency Syndromes 1994;7(3):254‐60. - PubMed
Beeson 2002 {published data only}
    1. Beeson WH, Rachel JD. Valacyclovir prophylaxis for herpes simplex virus infection or infection recurrence following laser skin resurfacing. Dermatologic Surgery 2002;28(4):331‐6. - PubMed
Belec 2006 {published data only}
    1. Belec L, Gresenguet G, Khonde N, Weiss H, LeGoff J, Frost E, et al. Impact of herpes simplex virus (HSV)‐2 episodic therapy on HIV‐1 and HSV‐2 genital shedding and ulcer healing among women in Ghana and the Central African Republic: randomized double‐blind placebo‐controlled trial (ANRS 1212 study). International Journal of STD & AIDS 2006;17(Suppl 1):26.
Bernstein 1984 {published data only}
    1. Bernstein DI, Lovett MA, Bryson YJ. The effects of acyclovir on antibody response to herpes simplex virus in primary genital herpetic infections. Journal of Infectious Diseases 1984;150(1):7‐13. - PubMed
Bierman 1981 {published data only}
    1. Bierman SM, Kirkpatrick W, Fernandez H. Clinical efficacy of ribavirin in the treatment of genital herpes simplex virus infection. Chemotherapy 1981;27(2):139‐45. - PubMed
Blough 1979 {published data only}
    1. Blough HA, Giuntoli RL. Successful treatment of human genital herpes infection with 2‐deoxy‐D‐glucose. JAMA 1979;241:2798‐801. - PubMed
Bollen 2008 {published data only}
    1. Bollen LJM, Whitehead SJ, Mock PA, Leelawiwat W, Asavapiriyanont S, Chalermchockchareonkit A, et al. Maternal herpes simplex virus type 2 coinfection increases the risk of perinatal HIV transmission: possibility to further decrease transmission?. AIDS 2008;22(10):1169‐76. - PubMed
Brocklehurst 1990 {published data only}
    1. Brocklehurst P, Carney O, Helson K, Kinghorn G, Mercey D, Mindel A. Acyclovir, herpes, and pregnancy. Lancet 1990;336(8730):1594‐5. - PubMed
Cattamanchi 2011 {published data only}
    1. Cattamanchi A, Saracino M, Selke S, Huang ML, Magaret A, Celum C, et al. Treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus‐8 replication in HIV‐1 seropositive men. Journal of Medical Virology 2011;83(10):1696‐703. - PMC - PubMed
Celum 2008 {published data only}
    1. Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany‐Moretlwe S, et al. Effect of aciclovir on HIV‐1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: A randomised, double‐blind, placebo‐controlled trial. Lancet 2008;371(9630):2109‐19. - PMC - PubMed
Celum 2010 {published data only}
    1. Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N, et al. Acyclovir and transmission of HIV‐1 from persons infected with HIV‐1 and HSV‐2. New England Journal of Medicine 2010;362(5):427‐39. - PMC - PubMed
Chen 2000 {published data only}
    1. Chen XS, Han GZ, Guo ZP, Lu NZ, Chen J, Wang JB, et al. A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double‐blind, multicentre trial. International Journal of STD & AIDS 2000;11(9):568‐73. - PubMed
Clewell 2012 {published data only}
    1. Clewell A, Barnes M, Endres JR, Ahmed M, Ghambeer DKS. Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericum perforatum on patients with herpes skin lesions: A comparative, randomized controlled trial. Journal of Drugs in Dermatology 2012;11(2):209‐15. - PubMed
Conant 2002 {published data only}
    1. Conant, MA, Schacker TW, Murphy RL, Gold J, Crutchfield LT, Crooks RJ, et al. Valaciclovir versus aciclovir for herpes simplex virus infection in HIV‐infected individuals: two randomized trials. International Journal of STD & AIDS 2002;13(1):12‐21. - PubMed
Cowan 2008 {published data only}
    1. Cowan FMPS, Barlow KL, Langhaug LF, Jaffar S, Hargrove JW, Robinson NJ, et al. A randomised placebo‐controlled trial to explore the effect of suppressive therapy with acyclovir on genital shedding of HIV‐1 and herpes simplex virus type 2 among Zimbabwean sex workers. Sexually Transmitted Infections 2008;84(7):548‐53. - PubMed
Crespi 1988 {published data only}
    1. Crespi H, Mora E, Pueyo S, Jaimovich L, Stringa S, Raimondo E, et al. Therapeutic use of human leukocyte interferon in dermatologic disorders caused by herpes simplex virus: Multicenter study. Medicina Cutanea Ibero‐Latino‐Americana 1988;16(6):459‐65. - PubMed
Dannenmaier 1985 {published data only}
    1. Dannenmaier B, Hempel B. Chemotherapy of herpes simplex. Therapiewoche 1985;35(27):3276‐9.
Delany 2009 {published data only}
    1. Delany SMN, Clayton T, Akpomiemie G, Capovilla A, Legoff J, Belec L, et al. Impact of aciclovir on genital and plasma HIV‐1 RNA in HSV‐2/HIV‐1 co‐infected women: a randomized placebo‐controlled trial in South Africa. AIDS 2009;23(4):461‐9. - PMC - PubMed
Diaz‐Mitoma 1998 {published data only}
    1. Diaz‐Mitoma F, Sibbald RG, Shafran SD, Boon R, Saltzman RL. Oral famciclovir for the suppression of recurrent genital herpes: a randomized controlled trial. JAMA 1998;280(10):887‐92. - PubMed
    1. Ritzmann P. Expensive long‐term care with virustatic drugs frequently reduces herpes genitalis episodes. Praxis 1999;88(24):1100. - PubMed
Drake 2010 {unpublished data only}
    1. Drake AL. HSV‐2 suppression among HIV‐1 infected pregnant and postpartum Kenyan women. Unpublished thesis from University of Washington.
Drake 2012 {published data only}
    1. Drake AL, Roxby AC, Ongecha‐Owuor F, Kiarie J, John‐Stewart G, Wald A, et al. Valacyclovir suppressive therapy reduces plasma and breast milk HIV‐1 RNA levels during pregnancy and postpartum: a randomized trial. Journal of Infectious Diseases 2012;205(3):366‐75. - PMC - PubMed
Emoedi 1983 {published data only}
    1. Emoedi G, Askenazy J, Suemeghy Z. Preliminary results on tolerance and toxicity tests using human fibroblast interferon (beta‐type) in patients with herpes genitalis infections. International Journal of Clinical Pharmacology Research 1983;3(4):275‐8. - PubMed
Fife 2008 {published data only}
    1. Fife KH, Warren TJ, Justus SE, Heitman CK, Hs2100275 Study Team. An international, randomized, double‐blind, placebo‐controlled, study of valacyclovir for the suppression of herpes simplex virus type 2 genital herpes in newly diagnosed patients. Sexually Transmitted Diseases 2008;35(7):668‐73. - PubMed
Garcia 2001 {published data only (unpublished sought but not used)}
    1. Garcia A, Garcia S, Sanchez JA, Garcia I, Lanchares JL. Valaciclovir in the treatment of initial infection by genital herpes virus: comparative study. Enfermedades Infecciosas y Microbiologia Clinica 2001;19(1):15‐8. - PubMed
Glezerman 1988 {published data only}
    1. Glezerman M, Lunenfeld E, Cohen V, Sarov I, Movshovitz M, Doerner T, et al. Placebo‐controlled trial of topical interferon in labial and genital herpes. Lancet 1988;1(8578):150‐2. - PubMed
Goodman 1975 {published data only}
    1. Goodman EL, Luby JP, Johnson MT. Prospective double blind evaluation of topical adenine arabinoside in male herpes progenitalis. Antimicrobial Agents and Chemotherapy 1975;8(6):693‐7. - PMC - PubMed
    1. Goodman EL, Luby JP, Johnson MT. Prospective double‐blind evaluation of topical adenine arabinoside in male herpes progenitalis [abstract]. British Journal of Venereal Diseases 1976;52(5):363. - PMC - PubMed
Guillaume 2002 {published data only}
    1. Guillaume JC. Antiviral and non‐antiviral general treatments for oro‐facial and genital herpes (pregnancy and neonates excluded). Annales de Dermatologie et de Venereologie 2002;129(4):625‐34. - PubMed
Gunby 1983 {published data only}
    1. Gunby P. Genital herpes research: many aim to tame maverick virus. JAMA 1983;250(18):2417‐9, 23‐4, 27. - PubMed
Guo 2001 {published data only}
    1. Guo SQ, Yang WG. Clinical observation of famciclovir synthesis therapy in treating genital herpes [Chinese]. Chinese Journal of Leprosy and Skin Disease 2001;17(2):116‐7.
Guo 2002 {published data only}
    1. Guo ZP, Liu HJ, Zhang YZ, Zhou GP, Jiang YJ. Clinical observation of recombinant human interferon (alpha)‐2b ointment for the treatment of genital herpes simplex and condyloma acuminatum. Journal of Clinical Dermatology 2002;31(3):169‐70.
Handsfield 2007 {published data only}
    1. Handsfield HH, Warren T, Werner M, Phillips JA. Suppressive therapy with valacyclovir in early genital herpes: a pilot study of clinical efficacy and herpes‐related quality of life. Sexually Transmitted Diseases 2007;34(6):339‐43. - PubMed
Harris 1995 {published data only (unpublished sought but not used)}
    1. Harris JRW. Treatment of the first episode genital herpes with famciclovir. Journal of the European Academy of Dermatology & Venereology 1995;5(Suppl 1):74.
Haverkos 1980 {published data only}
    1. Haverkos, HW, Pazin GJ, Armstrong JA, Ho M. Follow‐up of interferon treatment of herpes simplex. New England Journal of Medicine 1980;303(12):699‐700. - PubMed
Hellgren 1983 {published data only}
    1. Hellgren L, Hermann LS. Tromantadine hydrochloride in the treatment of herpes simplex. Results of a double‐blind therapeutic trial and an open prophylactic investigation. Dermatologica 1983;167(5):267‐72. - PubMed
Hilton 1978 {published data only}
    1. Hilton AL, Bushell TE, Waller D, Bright J. A trial of adenine arabinoside in genital herpes. British Journal of Venereal Diseases 1978;54(1):50‐2. - PMC - PubMed
Hjorth 1982 {published data only}
    1. Hjorth N, Osmundsen PE, Schmidt H, Thomsen K. Tromantadin HCl (Virumerz) in the treatment of herpes simplex. Ugeskrift for Laeger 1982;144(38):2786‐7. - PubMed
Holzgreve 2005 {published data only}
    1. Holzgreve H. Honey is better than aciclovir in herpes. MMW Fortschritte der Medizin 2005;147(3):18. - PubMed
Hu 2001 {published data only}
    1. Hu P, Cheng YJ, Yu KM. Clinical research on comparison of valaciclovir and aciclovir in treating genital herpes [Chinese]. Chinese Journal of Leprosy and Skin Disease 2001;17(2):107‐8.
Hudson 2004 {published data only}
    1. Hudson T. Propolis ointment for genital herpes. Alternative and Complementary Therapies 2004;10(5):287‐8.
Johnston 2011 {published data only}
    1. Johnston C, Saracino M, Kuntz S, Magaret A, Schiffer JT, Selke S, et al. Frequent breakthrough genital HSV‐2 shedding on standard and high dose valacyclovir. Sexually Transmitted Infections 2011;87:A79.
Johnston 2012 {published data only}
    1. Johnston C, Saracino M, Kuntz S, Magaret A, Selke S, Huang M‐l, et al. Standard‐dose and high‐dose daily antiviral therapy for short episodes of genital HSV‐2 reactivation: three randomised, open‐label, cross‐over trials. Lancet 2012;379(9816):641‐7. - PMC - PubMed
Jones 1979 {published data only}
    1. Jones R. Genital herpes and zinc. Medical Journal of Australia 1979;1(7):286. - PubMed
Kalinin 1990 {published data only}
    1. Kalinin Iu T, Vorob'ev AA, Bumialis VV, Denisov LA, Parfenov VV, Klenova AV, et al. The results of clinical trials and the prospects of using the Soviet preparation of human recombinant interferon alpha‐2 (reaferon) in medical practice. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 1990;9:61‐7. - PubMed
Kaufman 1978 {published data only}
    1. Kaufman RH, Adam E, Mirkovic RR, Melnick JL, Young RL. Treatment of genital herpes simplex virus infection with photodynamic inactivation. American Journal of Obstetrics and Gynecology 1978;132(8):861‐9. - PubMed
Koytchev 1999 {published data only}
    1. Koytchev R, Alken RG, Dundarov S. Hypericum‐extract LI 160 for the therapy of herpes simplex genitalis and labialis: results of two placebo‐controlled, randomised, double‐blind clinical trials. Zeitschrift fur Phytotherapie 1999;20(2):92.
Kuang 2008 {published data only}
    1. Kuang L, Hang YG, Liu X. Curative effects of Longdan Xiegan granule on treatment of damp‐heat genital herpes. Journal of Traditional Chinese Medicine University of Hunan [Hu Nan Zhong Yi Yao Da Xue Xue Bao] 2008;28:68‐70.
LeGoff 2007 {published data only}
    1. LeGoff J, Weiss HA, Gresenguet G, Nzambi K, Frost E, Hayes RJ, et al. Cervicovaginal HIV‐1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes. AIDS 2007;21(12):1569‐78. - PubMed
Leone 2007 {published data only (unpublished sought but not used)}
    1. Leone P, Warren T, Hamed K, Fife K, Wald A. Famciclovir reduces viral mucosal shedding in HSV‐seropositive persons. Sexually Transmitted Diseases 2007;34(11):900‐7. - PubMed
Levien 1995 {published data only}
    1. Levien TL, Baker DE. Famciclovir and ipratropium nasal spray. Hospital Pharmacy 1995;30(2):153‐4; 60‐2.
Li 1998 {published data only}
    1. Li WW, Zhang LR, Wu JJ. A randomised controlled trial of valaciclovir hydrochloride versus acylovir in the treatment of genital herpes [Chinese]. Journal of Clinical Dermatology 1998;27(3):175.
Loveless 1997 {published data only}
    1. Loveless M, Sacks SL, Harris JRW. Famciclovir in the management of first‐episode genital herpes. Infectious Diseases in Clinical Practice 1997;6(Suppl 1):12‐6.
Macotela 1984 {published data only}
    1. Macotela E, Suarez‐de la Torre RS, Hernandez‐Flores MF, Campos‐Macias P. Topical treatment of genital herpes simplex with a pregnene derivative. Gaceta Medica de Mexico 1984;120(2):59‐60. - PubMed
Mark 2007 {published data only}
    1. Mark KE, Corey L, Meng TC, Magaret AS, Huang ML, Selke S, et al. Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial. Journal of Infectious Diseases 2007;195(9):1324‐31. - PubMed
Martens 2009 {published data only (unpublished sought but not used)}
    1. Martens MG, Fife KH, Leone PA, Dix LP, Brennan CA. Once daily valacyclovir for reducing viral shedding in subjects newly diagnosed with genital herpes. Infectious Diseases in Obstetrics and Gynecology 2009;2009:105376. - PMC - PubMed
Mayaud 2009 {published data only}
    1. Mayaud P, Legoff J, Weiss HA, Gresenguet G, Nzambi K, Bouhlal H, et al. Impact of acyclovir on genital and plasma HIV‐1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV‐1‐infected African women with herpes ulcers: a randomized placebo‐controlled trial. Journal of Infectious Diseases 2009;200(2):216‐26. - PubMed
Meyers 1982 {published data only}
    1. Meyers JD, Wade JC, Mitchell CD, Saral R, Lietman PS, Durack DT, et al. Multicenter collaborative trial of intravenous acyclovir for treatment of mucocutaneous herpes simplex virus infection in the immunocompromised host. American Journal of Medicine 1982;73(1A):229‐35. - PubMed
Nagot 2007 {published data only}
    1. Nagot N, Ouedraogo A, Foulongne V, Konate I, Weiss HA, Vergne L, et al. Reduction of HIV‐1 RNA levels with therapy to suppress herpes simplex virus. New England Journal of Medicine 2007;356(8):790‐9. - PubMed
Niimura 1987 {published data only}
    1. Niimura MOA, Fukaya T, Tagami H, Tomita Y, Honda M, Ishibashi Y, et al. Dose finding study of aciclovir tablet for Herpes Simplex virus infection. Rinsho Iyaku [Journal of Clinical Therapeutics and Medicines] 1987;3(4):337‐50.
Nunes 2008 {published data only}
    1. Nunes Oda S, Pereira Rde S. Regression of herpes viral infection symptoms using melatonin and SB‐73: comparison with acyclovir. Journal of Pineal Research 2008;44(4):373‐8. - PubMed
Pang 2003 {published data only}
    1. Pang CC, Jiang LX, Bai L, Cui SS. Recombinant human alpha‐2b interferon in cream for treatment of genital herpes and herpes zoster. Journal of Dalian Medical University 2003;25(3):185‐7.
Paz‐Bailey 2009 {published data only}
    1. Paz‐Bailey G, Sternberg M, Puren AJ, Markowitz LE, Ballard R, Delany S, et al. Improvement in healing and reduction in HIV shedding with episodic acyclovir therapy as part of syndromic management among men: a randomized, controlled trial. Journal of Infectious Diseases 2009;200(7):1039‐49. - PubMed
Petersen 1993 {published data only}
    1. Petersen CS, Weismann K, Avnstorp C, Rasmussen LP, Fogh H, Tikjob G. Topical tromantadine in the treatment of genital herpes ‐ a double‐blind placebo‐controlled study. Danish Medical Bulletin 1993;40(4):506‐7. - PubMed
Phiri 2010 {published data only}
    1. Phiri S, Hoffman IF, Weiss HA, Martinson F, Nyirenda N, Kamwendo D, et al. Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV‐1 RNA among patients with genital ulcer disease in Malawi. Sexually Transmitted Infections 2010;86(5):345‐52. - PubMed
Posevaia 1991 {published data only}
    1. Posevaia TA, Tsukerman VG, Shuvaeva NI, Busuek IN, Barinskii IF. The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations. Voprosy Virusologii 1991;36(1):78‐80. - PubMed
Qadripur 1976 {published data only}
    1. Qadripur SA. Controlled clinical trial of the herpes antigen 'lupidon' against placebo. Aktuelle Dermatologie 1976;2(3):131‐6.
Rompalo 1988 {published data only}
    1. Rompalo AM, Mertz GJ, Davis LG, Benedetti JB, Critchlow C, Stamm WE, et al. Oral acyclovir for treatment of first‐episode herpes simplex virus proctitis. JAMA 1988;259(19):2879‐81. - PubMed
Roy 1982 {published data only}
    1. Roy RB. A double‐blind placebo‐controlled study of the use of co‐trimoxazole in the treatment of primary herpes genitalis. British Journal of Sexual Medicine 1982;9(86):22‐3; 41.
Ruhnek‐Forsbeck 1985 {published data only}
    1. Ruhnek‐Forsbeck M. Genital herpes: oral treatment with acyclovir. Scandinavian Journal of Infectious Diseases Supplement 1985;47:63‐6. - PubMed
Safrin 1991 {published data only}
    1. Safrin S, Crumpacker C, Chatis P, Davis R, Hafner R, Rush J, et al. A controlled trial comparing foscarnet with vidarabine for acyclovir‐resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. New England Journal of Medicine 1991;325(8):551‐5. - PubMed
Safrom 1995 {published data only}
    1. Safrin S, McKinley G, McKeough M, Robinson D, Spruance SL. Treatment of acyclovir‐unresponsive cutaneous herpes simplex virus infection with topically applied SP‐303 [abstract]. Genitourinary Medicine 1995;71(2):138. - PubMed
Saltzman 1994 {published data only}
    1. Saltzman R, Jurewicz R, Boon R. Safety of famciclovir in patients with herpes‐zoster and genital herpes. Antimicrobial Agents and Chemotherapy 1994;38(10):2454‐7. - PMC - PubMed
Schacker 1998 {published data only}
    1. Schacker T, Hu HL, Koelle DM, Zeh J, Saltzman R, Boon R, et al. Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV‐infected persons: A double‐blind, placebo‐controlled trial. Annals of Internal Medicine 1998;128(1):21‐8. - PubMed
Schneider 1985 {published data only}
    1. Schneider W, Schneider B. Therapeutic effects of tromantadin in different stages of herpes simplex infections. Therapiewoche 1985;35(37):4219‐25.
Scott 1996 {published data only (unpublished sought but not used)}
    1. Scott LL, Sanchez PJ, Jackson GL, Zeray F, Wendel Jr GD. Acyclovir suppression to prevent cesarean delivery after first‐episode genital herpes. Obstetrics and Gynecology 1996;87(1):69‐73. - PubMed
Scott 2001 {published data only}
    1. Scott LL, Hollier LM, McIntire D, Sanchez PJ, Jackson GL, Wendel Jr GD. Acyclovir suppression to prevent clinical recurrences at delivery after first episode genital herpes in pregnancy: an open‐label trial. Infectious Diseases in Obstetrics and Gynecology 2001;9(2):75‐80. - PMC - PubMed
Skinner 1983 {published data only}
    1. Skinner GRB. Lithium ointment for genital herpes. Lancet 1983;2(8344):288. - PubMed
Sperling 2008 {published data only}
    1. Sperling RS, Fife KH, Warren TJ, Dix LP, Brennan CA. The effect of daily valacyclovir suppression on herpes simplex virus type 2 viral shedding in HSV‐2 seropositive subjects without a history of genital herpes. Sexually Transmitted Diseases 2008;35(3):286‐90. - PubMed
Strachan 2011 {published data only}
    1. Strachan E, Saracino M, Selke S, Magaret A, Buchwald D, Wald A. The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double‐blind, placebo‐controlled, crossover trial of acyclovir in HSV‐2 seropositive women. Brain, Behavior, and Immunity 2011;25(7):1475‐81. - PMC - PubMed
Strand 2004 {published data only}
    1. Strand A. Once daily valaciclovir reduces transmission of genital herpes. Abstract PS06. 2004 Forum for Nordic Dermato‐venereology;9(Suppl 7):16.
Syed 1995a {published data only}
    1. Syed TA. Management of genital herpes in males with human leukocyte interferon‐a in a hydrophilic cream: A placebo‐controlled double blind study. Journal of the European Academy of Dermatology and Venereology 1995;5(Suppl 1):170.
Syed 1995b {published data only}
    1. Syed TA, Lundin S, Cheema KM, Kahlon RC, Khayyami M, Ahmad SA, et al. Human leukocyte interferon‐alpha in cream for the management of genital herpes in Asian women: a placebo‐controlled, double‐blind study. Journal of Molecular Medicine 1995;73(3):141‐4. - PubMed
Syed 1995c {published data only}
    1. Syed TA, Cheema KM, Kahlon BM, Kahlon RC, Khayyami M, Kahlon AM, et al. Human leukocyte interferon‐alpha in cream for the treatment of genital herpes in Asian males: a placebo‐controlled, double‐blind study. Dermatology 1995;191(1):32‐5. - PubMed
Syed 1997a {published data only}
    1. Syed TA, Afzal M, Ashfaq Ahmad S, Holt AH, Ali Ahmad S, Ahmad SH. Management of genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream: A placebo‐controlled double‐blind study. Journal of Dermatological Treatment 1997;8(2):99‐102.
Syed 1997b {published data only}
    1. Syed TA, Ahmadpour OA, Ahmad SA, Ahmad SH. Human leukocyte interferon‐alpha in a hydrophilic cream versus in a gel for the treatment of genital herpes in males: a placebo‐controlled, double‐blind, comparative study. Journal of Dermatology 1997;24(9):564‐8. - PubMed
Syed 1998a {published data only}
    1. Syed TA, Ahmadpour OA, Ahmad SA, Shamsi S. Treatment of genital herpes in males with imiquimod 1% cream: a randomised, double‐blind, placebo‐controlled study. Clinical Drug Investigation 1998;16(3):187‐91. - PubMed
Syed 1998b {published data only}
    1. Syed T. Management of genital herpes in males with imiquimod analog (5%) in cream: a placebo‐controlled, double‐blind study. Abstract P472; The 7th Congress of the European Academy of Dermatology and Venereology, Nice, 7‐11 October. Journal of the European Academy of Dermatology and Venereology 1998;11(Suppl 2):296.
Tardivo 2012 {published data only}
    1. Tardivo JP, Wainwright M, Baptista MS. Local clinical phototreatment of herpes infection in São Paulo. Photodiagnosis and Photodynamic Therapy 2012;9(2):118‐21. - PubMed
Taylor 1975 {published data only}
    1. Taylor PK, Doherty NR. Comparison of the treatment of herpes genitalis in men with proflavine photoinactivation, idoxuridine ointment, and normal saline. British Journal of Venereal Diseases 1975;51(2):125‐9. - PMC - PubMed
Twiss 2011 {published data only}
    1. Twiss J, McKenna S, Bloch M, Bonney MA. Patient and clinician perceived benefit of early consumption of famciclovir for the treatment of herpes outbreaks. Value in Health 2011;14(7):A266.
Vazquez 1998 {published data only}
    1. Vazquez E. Gel for resistant herpes. Positively Aware: the Monthly Journal of the Test Positive Aware Network 1998;9(1):16. - PubMed
Vennemann 1985 {published data only}
    1. Vennemann F, Tholen S, Wolters M. Human alpha‐leukocyte interferon. Preliminary results from a pilot study for the treatment of viral dermatoses. Fortschritte der Medizin 1985;103(42):977‐80. - PubMed
Wald 1995 {published data only}
    1. Wald A. Acyclovir suppresses subclinical shedding of HSV‐2 in the genital tract. Journal of the European Academy of Dermatology and Venereology 1995;5(Suppl 1):169.
Wald 1996 {published data only}
    1. Wald A, Zeh J, Barnum G, Davis LG, Corey L. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Annals of Internal Medicine 1996;124(1 Pt 1):8‐15. - PubMed
Wald 2008 {published data only}
    1. Wald A, Hughes J, Sanchez J, Reid S, Delany‐Moretlwe S, Cowan F, et al. Effect of aciclovir on HIV‐1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double‐blind, placebo‐controlled trial. Lancet 2008;371(9630):2109‐19. - PMC - PubMed
Walker 1985 {published data only}
    1. Walker E. The current status of acyclovir treatment of first episode and recurrent genital herpes simplex infection. Przeglad Dermatologiczny 1985;72(2):214‐6. - PubMed
Wenner 2005 {published data only}
    1. Wenner C, Nashelsky J. Antiviral agents for pregnant women with genital herpes. American Family Physician 2005;72(9):1807‐8. - PubMed
Wenz 1981 {published data only}
    1. Wenz C. Herpes on trial. Nature 1981;290(5809):727‐8. - PubMed
Whitley 1984 {published data only}
    1. Whitley RJ, Levin M, Barton N, Hershey BJ, Davis G, Keeney RE, et al. Infections caused by herpes simplex virus in the immunocompromised host: natural history and topical acyclovir therapy. Journal of Infectious Diseases 1984;150(3):323‐9. - PubMed
Yarnell 2009 {published data only}
    1. Yarnell E, Abascal K, Rountree R. Herbs for herpes simplex infections. Alternative and Complementary Therapies 2009;15(2):69‐74.
Zu 2010 {published data only}
    1. Zu Y, Fu Y, Wang W, Wu N, Liu W, Kong Y, et al. Comparative study on the antiherpetic activity of aqueous and ethanolic extracts derived from Cajanus cajan (L.) Millsp. Forschende Komplementarmedizin und Klassische Naturheilkunde 2010;17(1):15‐20. - PubMed

References to studies awaiting assessment

Grebeniuk 1981 {published data only}
    1. Grebeniuk VN, Marchenko VI, Parfenov VV, Pozhidaev II, Zubanova NA. Trial of the safety, reactivity and therapeutic effectiveness of an ointment containing swine leukocytic interferon. Antibiotiki 1981;26(3):145‐9. - PubMed
Skerk 2004 {published data only}
    1. Skerk V, Barsic B, Begovac J, Mahovlic V, Dostal M, Stojkovic A, et al. Randomized, open, comparative, multicentric, pilot study on the efficacy and tolerability of peroral valacyclovir and acyclovir in patients with genital herpes and varicella zoster virus infections. Infektoloski Glasnik 2004;24(4):189‐92.

Additional references

Azwa 2009
    1. Azwa A, Barton SE. Aspects of herpes simplex virus: a clinical review. Journal of Family Planning and Reproductive Health Care 2009;35(4):237‐42. - PubMed
Brown 2002
    1. Brown TJ, McCrary M, Tyring SK. Antiviral agents: Non‐antiretroviral [correction of Nonantiviral] drugs. Journal of the American Academy of Dermatology 2002;47(4):581‐99. - PubMed
Brown 2003
    1. Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 2003;289(2):203‐9. [DOI: ] - PubMed
Brown 2005
    1. Brown ZA, Gardella C, Wald A, Morrow RA, Corey L. Genital herpes complicating pregnancy. Obstetrics and Gynecology 2005;106(4):845‐56. [PUBMED: 16199646] - PubMed
CDC 2015
    1. Centers for Disease Control and Prevention. 2015 Sexually transmitted diseases treatment guideline. www.cdc.gov/std/tg2015/.
Cernik 2008
    1. Cernik C, Gallina K, Brodell RT. The treatment of Herpes Simplex infections: an evidence‐based review. Annals of Internal Medicine 2008;168:1137‐44. - PubMed
Chiu 2011
    1. Chiu HY, Tsai TF. Topical use of systemic drugs in dermatology: a comprehensive review. Journal of the American Academy of Dermatology 2011;65(5):1048. - PubMed
Corey 1983b
    1. Corey L, Adams HG, Brown ZA, Holmes KK. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Annals of Internal Medicine 1983;98(6):958‐72. - PubMed
Freeman 2006
    1. Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta‐analysis of longitudinal studies. AIDS 2006;20(1):73‐83. - PubMed
Gaby 2006
    1. Gaby AR. Natural remedies for Herpes simplex. Alternative Medicine Review 2006;11(2):93‐101. - PubMed
GRADEproGDT 2015 [Computer program]
    1. McMaster University (developed by Evidence Prime, Inc.). GRADEproGDT: GRADEpro Guideline Development Tool [www.guidelinedevelopment.org]. Hamilton: McMaster University (developed by Evidence Prime, Inc.), 2015.
Gupta 2002
    1. Gupta AK, Browne M, Bluhm R. Imiquimod: a review. Journal of Cutaneous Medicine and Surgery 2002;6(6):554‐60. - PubMed
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org. Available from www.cochrane‐handbook.org..
Huang 2012
    1. Huang W, Hu K, Luo S, Zhang M, Li C, Jin W, et al. Herpes simplex virus type 2 infection of human epithelial cells induces CXCL9 expression and CD4+ T cell migration via activation of p38‐CCAAT/enhancer‐binding protein‐beta pathway. Journal of Immunology 2012;188(12):6247‐57. - PubMed
IUSTI 2010
    1. IUSTI/WHO European STD guidelines Editorial Board. 2010 European guideline for the management of genital herpes. www.iusti.org/regions/europe/pdf/2010/Euro_Guideline_2010_herpes.pdf.
Jerath 2009
    1. Jerath VP, Mahajan VK. Does circumcision influence recurrences in herpes genitalis?. Indian Journal of Dermatology, Venereology and Leprology 2009;75(6):575‐8. [PUBMED: 19915236] - PubMed
Katze 2002
    1. Katze MG, He Y, Gale M Jr. Viruses and interferon: a fight for supremacy. Nature Reviews. Immunology 2002;2(9):675‐87. - PubMed
Kongkaew 2011
    1. Kongkaew C, Chaiyakunapruk N. Efficacy of Clinacanthus nutans extracts in patients with herpes infection: systematic review and meta‐analysis of randomised clinical trials. Complementary Therapies in Medicine 2011;19(1):47‐53. - PubMed
Le Cleach 2014
    1. Cleach L, Trinquart L, Do G, Maruani A, Lebrun‐Vignes B, Ravaud P, et al. Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients. Cochrane Database of Systematic Reviews 2014, Issue 8. [DOI: 10.1002/14651858.CD009036.pub2] - DOI - PMC - PubMed
Leung 2000
    1. Leung DT, Sacks SL. Current recommendations for the treatment of genital herpes. Drugs 2000; Vol. 60, issue 6:1329‐52. - PubMed
Malkin 2004
    1. Malkin JE. Epidemiology of genital herpes simplex virus infection in developed countries. Herpes 2004;11(Suppl 1):2e23A. - PubMed
Martin 2009
    1. Martin ET, Krantz E, Gottlieb SL, Magaret AS, Langenberg A, Stanberry L, et al. A pooled analysis of the effect of condoms in preventing HSV‐2 acquisition. Archives of Internal Medicine 2009;169(13):1233‐40. - PMC - PubMed
Moher 2009
    1. Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA Group. Preferred reporting items for systematic reviews and meta‐analyses: The PRISMA Statement. BMJ 2009;339:2535. - PMC - PubMed
Patel 2002
    1. Patel R. Progress in meeting today's demands in genital herpes: an overview of current management. Journal of Infectious Diseases 2002; Vol. 186 Suppl 1:S47‐56. - PubMed
RevMan 2014 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Stanley 2002
    1. Stanley MA. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clinical and Experimental Dermatology 2002;27(7):571‐7. - PubMed
Tobian 2009
    1. Tobian AA, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O. Male circumcision for the prevention of HSV‐2 and HPV infections and syphilis. New England Journal of Medicine 2009;360(13):1298‐309. [PUBMED: 19321868] - PMC - PubMed
Tobian 2012
    1. Tobian AA, Kigozi G, Redd AD, Serwadda D, Kong X, Oliver A. Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda. Journal of Infectious Diseases 2012;205(3):486‐90. [PUBMED: 22147796] - PMC - PubMed
Vajpayee 2000
    1. Vajpayee M, Malhotra N. Antiviral drugs against herpes infections. Indian Journal of Pharmacology 2000;32:330‐8.
Weiss 2004
    1. Weiss H. Epidemiology of herpes simplex virus type 2 infection in developing countries. Herpes 2004;11(Suppl 1):24e35A. - PubMed
Whitley 1998
    1. Whitley RJ, Kimberlin DW, Roizman B. Herpes Simplex viruses. Clinical Infectious Diseases 1998;26(3):541‐55. - PubMed
Workowski 2010
    1. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. Morbidity and Mortality Weekly Report 2010;59(RR‐12):1‐116. - PubMed
Zhong 2012
    1. Zhong M‐G, Xiang Y‐F, Qiu X‐X, Liu Z, Kitazato K, Wang Y‐F. Natural products as a source of anti‐herpes simplex virus agents. RSC Advances 2012 Oct 31 [Epub ahead of print]. [DOI: 10.1039/C2RA21464D] - DOI

References to other published versions of this review

Heslop 2013
    1. Heslop R, Jordan V, Trivella M, Papastamopoulos V, Roberts H. Interventions for men and women with their first episode of genital herpes. Cochrane Database of Systematic Reviews 2013, Issue 7. [DOI: 10.1002/14651858.CD010684] - DOI - PMC - PubMed