Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies - PubMed

Affiliations

• PMID: 28002638
• DOI: 10.1002/cpt.603

Review

Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies

C Lanvers-Kaminsky et al. Clin Pharmacol Ther. 2017 Apr.

Abstract

Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.

Similar articles

• Pharmacogenetics of drug-induced ototoxicity caused by aminoglycosides and cisplatin.

  Lanvers-Kaminsky C, Ciarimboli G. Lanvers-Kaminsky C, et al. Pharmacogenomics. 2017 Dec;18(18):1683-1695. doi: 10.2217/pgs-2017-0125. Epub 2017 Nov 27. Pharmacogenomics. 2017. PMID: 29173064 Review.

• Understanding drug ototoxicity: molecular insights for prevention and clinical management.

  Yorgason JG, Fayad JN, Kalinec F. Yorgason JG, et al. Expert Opin Drug Saf. 2006 May;5(3):383-99. doi: 10.1517/14740338.5.3.383. Expert Opin Drug Saf. 2006. PMID: 16610968 Review.

• Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

  Kros CJ, Steyger PS. Kros CJ, et al. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a033548. doi: 10.1101/cshperspect.a033548. Cold Spring Harb Perspect Med. 2019. PMID: 30559254 Free PMC article. Review.

• Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

  Schacht J, Talaska AE, Rybak LP. Schacht J, et al. Anat Rec (Hoboken). 2012 Nov;295(11):1837-50. doi: 10.1002/ar.22578. Epub 2012 Oct 8. Anat Rec (Hoboken). 2012. PMID: 23045231 Free PMC article. Review.

• Ototoxicity in childhood: Recommendations of the CODEPEH (Commission for the Early Detection of Childhood Hearing Loss) for prevention and early diagnosis.

  Núñez-Batalla F, Jáudenes-Casaubón C, Sequí-Canet JM, Vivanco-Allende A, Zubicaray-Ugarteche J. Núñez-Batalla F, et al. Acta Otorrinolaringol Esp (Engl Ed). 2022 Jul-Aug;73(4):255-265. doi: 10.1016/j.otoeng.2022.07.002. Epub 2022 Jul 21. Acta Otorrinolaringol Esp (Engl Ed). 2022. PMID: 35872300

Cited by

• Hearing Loss and Oxidative Stress: A Comprehensive Review.

  Maniaci A, La Via L, Lechien JR, Sangiorgio G, Iannella G, Magliulo G, Pace A, Mat Q, Lavalle S, Lentini M. Maniaci A, et al. Antioxidants (Basel). 2024 Jul 14;13(7):842. doi: 10.3390/antiox13070842. Antioxidants (Basel). 2024. PMID: 39061910 Free PMC article. Review.

• The role of genetic variants in the prediction of hearing loss due to cisplatin chemoradiotherapy.

  Duinkerken CW, Chiodo S, Hueniken K, Hauptmann M, Jóźwiak K, Cheng D, Hope A, Liu G, Zuur CL. Duinkerken CW, et al. Cancer Med. 2024 Aug;13(16):e7465. doi: 10.1002/cam4.7465. Cancer Med. 2024. PMID: 39159054 Free PMC article.

• Exacerbation of Cisplatin Cellular Toxicity by Regulation of the Human Organic Cation Transporter 2 through Angiotensin II.

  Kantauskaite M, Hucke A, Snieder B, Ciarimboli G. Kantauskaite M, et al. Int J Mol Sci. 2022 Dec 14;23(24):15866. doi: 10.3390/ijms232415866. Int J Mol Sci. 2022. PMID: 36555515 Free PMC article.

• Use of Zebrafish in Drug Discovery Toxicology.

  Cassar S, Adatto I, Freeman JL, Gamse JT, Iturria I, Lawrence C, Muriana A, Peterson RT, Van Cruchten S, Zon LI. Cassar S, et al. Chem Res Toxicol. 2020 Jan 21;33(1):95-118. doi: 10.1021/acs.chemrestox.9b00335. Epub 2019 Nov 16. Chem Res Toxicol. 2020. PMID: 31625720 Free PMC article. Review.

• Pharmacokinetics and pharmacodynamics of peptide antibiotics.

  Bian X, Qu X, Zhang J, Nang SC, Bergen PJ, Tony Zhou Q, Chan HK, Feng M, Li J. Bian X, et al. Adv Drug Deliv Rev. 2022 Apr;183:114171. doi: 10.1016/j.addr.2022.114171. Epub 2022 Feb 18. Adv Drug Deliv Rev. 2022. PMID: 35189264 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information